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2019年肺生物学与疾病中的干细胞、细胞疗法及生物工程

Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019.

作者信息

Wagner Darcy E, Ikonomou Laertis, Gilpin Sarah E, Magin Chelsea M, Cruz Fernanda, Greaney Allison, Magnusson Mattias, Chen Ya-Wen, Davis Brian, Vanuytsel Kim, Rolandsson Enes Sara, Krasnodembskaya Anna, Lehmann Mareike, Westergren-Thorsson Gunilla, Stegmayr John, Alsafadi Hani N, Hoffman Evan T, Weiss Daniel J, Ryan Amy L

机构信息

Lung Bioengineering and Regeneration, Dept of Experimental Medicine, Wallenberg Center for Molecular Medicine and Lund Stem Cell Center, Faculty of Medicine, Lund University, Lund, Sweden.

These authors contributed equally.

出版信息

ERJ Open Res. 2020 Oct 19;6(4). doi: 10.1183/23120541.00123-2020. eCollection 2020 Oct.

Abstract

A workshop entitled "Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases" was hosted by the University of Vermont Larner College of Medicine in collaboration with the National Heart, Lung and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, the International Society for Cell and Gene Therapy and the Pulmonary Fibrosis Foundation. The event was held from July 15 to 18, 2019 at the University of Vermont, Burlington, Vermont. The objectives of the conference were to review and discuss the current status of the following active areas of research: 1) technological advancements in the analysis and visualisation of lung stem and progenitor cells; 2) evaluation of lung stem and progenitor cells in the context of their interactions with the niche; 3) progress toward the application and delivery of stem and progenitor cells for the treatment of lung diseases such as cystic fibrosis; 4) progress in induced pluripotent stem cell models and application for disease modelling; and 5) the emerging roles of cell therapy and extracellular vesicles in immunomodulation of the lung. This selection of topics represents some of the most dynamic research areas in which incredible progress continues to be made. The workshop also included active discussion on the regulation and commercialisation of regenerative medicine products and concluded with an open discussion to set priorities and recommendations for future research directions in basic and translation lung biology.

摘要

佛蒙特大学拉纳医学院联合美国国立心肺血液研究所、α-1基金会、囊性纤维化基金会、国际细胞与基因治疗协会以及肺纤维化基金会,主办了一场名为“肺生物学与疾病中的干细胞、细胞疗法及生物工程”的研讨会。该活动于2019年7月15日至18日在佛蒙特州伯灵顿的佛蒙特大学举行。会议的目标是回顾和讨论以下活跃研究领域的现状:1)肺干细胞和祖细胞分析与可视化的技术进展;2)在肺干细胞和祖细胞与生态位相互作用的背景下对其进行评估;3)在将干细胞和祖细胞应用于治疗诸如囊性纤维化等肺部疾病方面取得的进展;4)诱导多能干细胞模型及其在疾病建模中的应用进展;5)细胞疗法和细胞外囊泡在肺免疫调节中的新作用。这些主题的选择代表了一些最具活力的研究领域,在这些领域中仍在不断取得令人难以置信的进展。研讨会还积极讨论了再生医学产品的监管和商业化问题,并以一场公开讨论结束,以确定基础和转化肺生物学未来研究方向的优先事项和建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac5/7569162/a2a93d06f7e0/00123-2020.01.jpg

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