排卵前短期应用布洛芬。
Short-term application of ibuprofen before ovulation.
作者信息
Kohl Schwartz A S, Burkard S, Mitter V R, Leichtle A B, Fink A, Von Wolff M
机构信息
University Women's Hospital, Division of Gynecological Endocrinology and Reproductive Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.
Department of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland.
出版信息
Facts Views Vis Obgyn. 2020 Oct 8;12(3):179-184.
AIM OF THE STUDY
The aim was to analyse if ibuprofen, as a non-selective cyclooxygenase (COX) inhibitor, has any negative effect on oocyte competence and embryo quality. COX- inhibitors are popular over-the-counter analgesics. Whereas selective COX inhibitors have been shown to impair female fertility, data on non-selective COX inhibitors are poor. Hence, they have not been recommended for women trying to conceive.
METHODS
This is an observational study comparing ibuprofen exposed and unexposed women from 18 to 42 years of age, using the model of natural cycle in vitro fertilisation (IVF) to determine oocyte and embryo quality. Follicular growth was monitored and if the follicle was mature (≥ 15mm size and estimated oestradiol level of ≥ 800pmol/l), ovulation was triggered. Women with luteinising hormone (LH) surge received 400mg ibuprofen every 8 hours to postpone ovulation, whereas women without LH surge received none (controls). Oocyte retrieval rate, oocyte maturity, fertilization rate, embryo development and embryo quality as well as implantation rate were analysed.
RESULTS
Of the 111 women included, 63 received ibuprofen, and 48 did not. Rates of mature oocytes and implantation rate did not differ. Logistic regression showed no significant association of ibuprofen intake, LH- level or reason for infertility on embryo quality.
CONCLUSION
Based on our results, we suggest that, particularly within natural cycle IVF, ibuprofen does no harm around ovulation as analgesic treatment.
研究目的
本研究旨在分析作为非选择性环氧化酶（COX）抑制剂的布洛芬是否对卵母细胞能力和胚胎质量有任何负面影响。COX抑制剂是常用的非处方镇痛药。虽然选择性COX抑制剂已被证明会损害女性生育能力，但关于非选择性COX抑制剂的数据却很匮乏。因此，不建议试图受孕的女性使用。
方法
这是一项观察性研究，比较18至42岁使用自然周期体外受精（IVF）模型的布洛芬暴露组和未暴露组女性，以确定卵母细胞和胚胎质量。监测卵泡生长情况，若卵泡成熟（直径≥15mm且估计雌二醇水平≥800pmol/l），则触发排卵。出现促黄体生成素（LH）峰的女性每8小时服用400mg布洛芬以推迟排卵，而未出现LH峰的女性不服用（对照组）。分析卵母细胞采集率、卵母细胞成熟度、受精率、胚胎发育、胚胎质量以及着床率。
结果
纳入的111名女性中，63名服用了布洛芬，48名未服用。成熟卵母细胞率和着床率无差异。逻辑回归显示，布洛芬摄入、LH水平或不孕原因与胚胎质量之间无显著关联。
结论
基于我们的研究结果，我们建议，尤其是在自然周期IVF中，布洛芬作为镇痛治疗在排卵前后无害。
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