Lee Sang-Yeol, Ryu Han-Seung, Choi Suck-Chei, Jang Seung-Ho
Department of Psychiatry, Wonkwang University School of Medicine, Iksan, Korea.
Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Clin Psychopharmacol Neurosci. 2020 Nov 30;18(4):580-586. doi: 10.9758/cpn.2020.18.4.580.
: The purpose of this study was to analyze the symptoms of depression, anxiety, and childhood trauma in functional gastrointestinal disorder (FGID) patients who visited the brain-gut axis clinic.
The study participants included 99 individuals who were diagnosed with FGID by gastroenterologists, 88 individuals who had no FGID but showed symptoms of FGID based on the Rome criteria, and 79 individuals who did not show any symptoms or were diagnosed with FGID. Symptoms of depression, anxiety, and childhood trauma were evaluated by the Korean version of Beck-depression inventory-II (K-BDI-II), Korean version of Beck anxiety inventory (K-BAI), and Korean version of childhood trauma questionnaire (K-CTQ), respectively.
The BDI score, BAI score, and CTQ score were significantly different between the groups. The group also had higher odds for developing anxiety as compared to the control group (odds ratio [OR] = 10.215, 95% confidence intervals [CI]: 2.49-41.76). Additionally, the FGID group had higher odds for developing symptoms of depression (OR = 5.554, 95% CI: 2.06-14.97) and experiencing physical violence (OR = 3.128, 95% CI: 1.53-6.38) than the non-FGID group.
This study showed that FGID patients were more likely to have symptoms of depression, severe anxiety, and childhood trauma, which were the risk factors of FGID.
本研究旨在分析前往脑-肠轴诊所就诊的功能性胃肠疾病（FGID）患者的抑郁、焦虑和童年创伤症状。
研究参与者包括99名经胃肠病学家诊断为FGID的个体、88名虽无FGID但根据罗马标准显示有FGID症状的个体以及79名未表现出任何症状或未被诊断为FGID的个体。抑郁、焦虑和童年创伤症状分别通过韩国版贝克抑郁量表第二版（K-BDI-II）、韩国版贝克焦虑量表（K-BAI）和韩国版童年创伤问卷（K-CTQ）进行评估。
各组之间的BDI评分、BAI评分和CTQ评分存在显著差异。与对照组相比，该组发生焦虑的几率也更高（优势比[OR]=10.215，95%置信区间[CI]：2.49-41.76）。此外，FGID组发生抑郁症状（OR=5.554，95%CI：2.06-14.97）和遭受身体暴力（OR=3.128，95%CI：1.53-6.38）的几率高于非FGID组。
本研究表明，FGID患者更有可能出现抑郁、严重焦虑和童年创伤症状，这些都是FGID的危险因素。
