Ariga Hiroyuki, Yonezaki Syun, Kashimura Junya, Takayashiki Norio
Department of Gastroenterology, Mito Kyodo General Hospital, 3-2-7 Miya-machi, Mito, Ibaraki, 310-0015, Japan.
Department of General Medicine, Mito Kyodo General Hospital, Mito, Japan.
Clin J Gastroenterol. 2021 Feb;14(1):382-385. doi: 10.1007/s12328-020-01269-3. Epub 2020 Oct 29.
Pancreatic panniculitis is a rare complication of pancreatic diseases. We aimed to evaluate a case of pancreatic panniculitis. A 58-year-old woman was referred to our hospital with complaints of painful cutaneous nodules on her limbs. Various diagnostic tests confirmed pancreatic panniculitis and pancreatic adenosquamous carcinoma. We diagnosed pancreatic panniculitis by a skin nodule biopsy that revealed fine basophilic material within anucleate cells and neutrophil infiltration. Abdominal imaging detected a tumor with necrosis on the pancreas and endoscopic ultrasound-guided fine-needle aspiration revealed it as an adenocarcinoma. The patient underwent pancreatoduodenectomy after neoadjuvant chemotherapy. The tumor was composed of differentiated adenocarcinoma and squamous cell carcinoma and diagnosed as adenosquamous carcinoma. This is the first report of pancreatic panniculitis in a patient with adenosquamous cell carcinoma of the pancreas.
胰腺性脂膜炎是胰腺疾病的一种罕见并发症。我们旨在评估一例胰腺性脂膜炎病例。一名58岁女性因四肢出现疼痛性皮肤结节而转诊至我院。各种诊断检查确诊为胰腺性脂膜炎和胰腺腺鳞癌。我们通过皮肤结节活检诊断为胰腺性脂膜炎，活检显示无核细胞内有细小嗜碱性物质和中性粒细胞浸润。腹部影像学检查发现胰腺有一个伴有坏死的肿瘤，内镜超声引导下细针穿刺活检显示为腺癌。该患者在新辅助化疗后接受了胰十二指肠切除术。肿瘤由分化型腺癌和鳞状细胞癌组成，诊断为腺鳞癌。这是首例胰腺腺鳞癌患者并发胰腺性脂膜炎的报告。
