Jiangsu Collaborative Innovation Center for Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
Langmuir. 2020 Nov 10;36(44):13263-13273. doi: 10.1021/acs.langmuir.0c02219. Epub 2020 Oct 30.
Postoperative wound repair of solid tumors resection, which is afflicted by the complex tumor microenvironment (TME) and associated with the bacterial infection, is worsening and demands prompt solutions. Meanwhile, the tumor recurrence is frequently seen during the subsequent treatment due to intraoperative bleeding. For effective postoperative cancer therapy, nanoscale carriers occur as innovative and sensitive tools for monitoring the wound state, avoiding bacterial infection, and restraining tumor recurrence. Herein, a multifunctional sodium alginate (SA) hydrogel immobilizing hemoglobin (Hb) and pH-sensitive fluorescent changing carbon quantum dots (CQDs) is rationally designed. The multifunctionalization of obtained alginate@hemoglobin@CQDs hydrogel (SA@Hb@CQDs) simultaneously consists of detection, hemostasis, and chemodynamic therapy (CDT) with monitoring of wound pH based on CQDs, stanching triggered from SA hydrogel, and Fenton reaction induced by Hb. We demonstrated that SA@Hb@CQDs can stop bleeding quickly, collect wound status information in real-time, and avert bacterial infection as well as inhibit local tumor recurrence effectively. Therefore, our work provides a promising combination approach for postoperative tumor therapy.
实体肿瘤切除术后的伤口修复，受到复杂的肿瘤微环境（TME）和相关细菌感染的影响，情况正在恶化，需要迅速解决。同时，由于术中出血，随后的治疗中经常会出现肿瘤复发。为了有效进行术后癌症治疗，纳米级载体作为监测伤口状态、避免细菌感染和抑制肿瘤复发的创新和敏感工具出现。在这里，我们合理设计了一种多功能化的海藻酸钠（SA）水凝胶，其固定有血红蛋白（Hb）和 pH 敏感的荧光变色碳量子点（CQDs）。所得到的海藻酸钠@血红蛋白@CQDs 水凝胶（SA@Hb@CQDs）的多功能化同时包括基于 CQDs 的伤口 pH 监测的检测、止血和化学动力学治疗（CDT）、触发于 SA 水凝胶的止血以及由 Hb 诱导的 Fenton 反应。我们证明了 SA@Hb@CQDs 可以快速止血，实时收集伤口状态信息，有效避免细菌感染并抑制局部肿瘤复发。因此，我们的工作为术后肿瘤治疗提供了一种很有前景的联合方法。
