Anhui Medical University, Hefei, China; Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China.
Anhui Medical University, Hefei, China; Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China.
Am J Otolaryngol. 2021 Jan-Feb;42(1):102766. doi: 10.1016/j.amjoto.2020.102766. Epub 2020 Oct 22.
To compare the therapeutic effect of PPI and combined treatment in the treatment of patients with recurrent laryngeal contact granuloma.
The clinical data of 299 patients with recurrent laryngeal contact granuloma treated with PPI or combined treatment (PPI with glucocorticoid injection into granuloma by the thyroglossal approach) from February 2013 to June 2019 were analyzed retrospectively. Patients were divided into two subgroups: PPI and combined treatment. The cure rates, recurrence rates and cure time of the two subgroups were compared and analyzed separately. Than we can get the optimal treatment of the two treatment in the treatment of recurrent patients.
In recurrent patients, the cure rate (81.20%) and recurrence rate (3%) of combined treatment were superior to those of PPI (57.58%) and recurrence rate (12.12%); (P < 0.05). The cure time of PPI was longer than that of combination therapy (P < 0.001).
The therapeutic effect of combined treatment is better than that of PPI in patients with recurrence. At the same time, combined treatment is an effective treatment for recurrent granuloma and can be used as a first-line treatment for recurrent laryngeal contact granuloma.
比较质子泵抑制剂（PPI）与联合治疗对复发性喉接触性肉芽肿患者的治疗效果。
回顾性分析 2013 年 2 月至 2019 年 6 月采用 PPI 或联合治疗（经甲状舌骨途径将 PPI 与糖皮质激素注射入肉芽肿内）治疗的 299 例复发性喉接触性肉芽肿患者的临床资料。将患者分为 PPI 组和联合治疗组，分别比较和分析两组的治愈率、复发率和治愈时间。然后我们可以得到两种治疗方法在治疗复发性患者的最佳治疗效果。
在复发性患者中，联合治疗的治愈率（81.20%）和复发率（3%）优于 PPI 组（57.58%和 12.12%）（P<0.05）。PPI 组的治愈时间长于联合治疗组（P<0.001）。
联合治疗对复发性患者的疗效优于 PPI。同时，联合治疗是治疗复发性肉芽肿的有效方法，可作为复发性喉接触性肉芽肿的一线治疗方法。
