Department of Otolaryngology Head and Neck Surgery, Sixth Medical Center of PLA General Hospital; College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.
Eur Arch Otorhinolaryngol. 2021 May;278(5):1499-1504. doi: 10.1007/s00405-020-06595-3. Epub 2021 Jan 13.
To evaluate the short-term efficacy of transcutaneous glucocorticoid injection for laryngeal contact granuloma in females.
A total of 14 female patients with laryngeal contact granuloma treated in our outpatient department from November 2017 to January 2020 were included in the study. Inspiratory-phase laryngoscopy images were collected before treatment and 1 month after each injection, and the lesion size was measured and evaluated with ImageJ software.
Two patients achieved complete remission after one injection, with a percent reduction of 100%. After two injections, 4 patients achieved complete remission, with a percent reduction ranging from 96% to 100%. After 3 injections, 4 patients achieved complete remission (including one patient with bilateral lesions), and the percent reduction ranged from 95% to 100%. Three patients achieved incomplete remission, with a percent reduction of 46%, 55%, and 81%, respectively. In one case, there was no remission, and the granuloma increased in size after treatment.
In women with laryngeal contact granuloma, transcutaneous glucocorticoid injection therapy can quickly resolve the granuloma in a short period.
评估经皮糖皮质激素注射治疗女性喉接触性肉芽肿的短期疗效。
本研究纳入了 2017 年 11 月至 2020 年 1 月在我科门诊治疗的 14 例女性喉接触性肉芽肿患者。在治疗前和每次注射后 1 个月采集吸气相喉内窥镜图像，使用 ImageJ 软件测量并评估病变大小。
2 例患者单次注射后完全缓解，缓解率为 100%。4 例患者接受 2 次注射后完全缓解，缓解率为 96%至 100%。4 例患者接受 3 次注射后完全缓解（包括 1 例双侧病变），缓解率为 95%至 100%。3 例患者未完全缓解，缓解率分别为 46%、55%和 81%。1 例患者无缓解，治疗后肉芽肿增大。
在女性喉接触性肉芽肿患者中，经皮糖皮质激素注射治疗可在短期内迅速消退肉芽肿。
