Gao Shupei, Tang Kun, Chen Jinqing, Wang Jianmiao
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, China.
Medicine (Baltimore). 2020 Oct 30;99(44):e23006. doi: 10.1097/MD.0000000000023006.
Interleukin-10(IL-10) is an immunosuppressive cytokine and plays an important role in inflammation and cancers. Numerous studies have explored the association between single nucleotide polymorphisms of IL-10 and leukemia, but their results were conflicting, so we performed this meta-analysis to elucidate the association between 3 common single nucleotide polymorphisms of IL-10 (rs1800896, rs1800871 and rs1800872) and risk of leukemia.We conducted a comprehensive research in Pubmed, Chinese Biomedical Literature Database disc and Embase using related terms. After strict selection, 18 studies with 2264 cases and 3846 controls were included into this meta-analysis. Odds ratio and 95% confidence interval were used to evaluate the strength of the association.We found that polymorphism of IL-10 -1082A/G was associated with decreased risk of leukemia both in overall analysis and in stratified analysis according to ethnicity and cancer type. A strong relationship was also uncovered between polymorphism of IL-10 -592C/A and increased risk of leukemia in non-Chinese.GG genotype of IL-10 -1082A/G is associated with decreased risk of leukemia, especially chronic lymphocytic leukemia. CC genotype of -592C/A is associated with decreased risk of leukemia in non-Chinese.
白细胞介素-10（IL-10）是一种免疫抑制细胞因子，在炎症和癌症中发挥重要作用。众多研究探讨了IL-10单核苷酸多态性与白血病之间的关联，但其结果相互矛盾，因此我们进行了这项荟萃分析，以阐明IL-10的3种常见单核苷酸多态性（rs1800896、rs1800871和rs1800872）与白血病风险之间的关联。我们使用相关术语在PubMed、中国生物医学文献数据库和Embase中进行了全面检索。经过严格筛选，18项研究（共2264例病例和3846例对照）被纳入该荟萃分析。采用比值比和95%置信区间来评估关联强度。我们发现，在总体分析以及按种族和癌症类型进行的分层分析中，IL-10 -1082A/G多态性与白血病风险降低相关。在非中国人中，还发现IL-10 -592C/A多态性与白血病风险增加之间存在密切关系。IL-10 -1082A/G的GG基因型与白血病风险降低相关，尤其是慢性淋巴细胞白血病。-592C/A的CC基因型与非中国人白血病风险降低相关。
