基因rs1800896多态性与前列腺癌风险相关。

gene rs1800896 polymorphism is associated with the risk of prostate cancer.

作者信息

Chen Hao, Tang Jilei, Shen Nan, Ren Kewei

机构信息

Department of Urology, The First Hospital of Jiaxing, Jiaxing 314001, China.

Department of Orthopedics, Qidong People's Hospital, Nantong 226200, China.

出版信息

Oncotarget. 2017 Aug 3;8(39):66204-66214. doi: 10.18632/oncotarget.19857. eCollection 2017 Sep 12.

Numerous studies have uncovered the association of Interleukin-10 () gene rs1800896 polymorphism with the risk of prostate cancer (PCa); however, their conclusions were inconsistent. Therefore, we conducted this meta-analysis to evaluate the role of rs1800896 polymorphism in the risk of PCa. 16 eligible studies in 15 articles involving 6,301 cases and 6,510 controls were identified by researching PubMed, Google, CNKI, and EMBASE up to April 1, 2017. Our results revealed that rs1800896 polymorphism was associated with the decreased risk of PCa under the homozygous model. Subgroup analysis by ethnicity revealed that rs1800896 polymorphism decreased the risk of PCa among Caucasians. In conclusion, gene rs1800896 polymorphism is associated with the decreased risk of PCa. Larger studies with more diverse ethnic populations are needed to confirm these results.

众多研究揭示了白细胞介素-10（IL-10）基因rs1800896多态性与前列腺癌（PCa）风险之间的关联；然而，他们的结论并不一致。因此，我们进行了这项荟萃分析，以评估rs1800896多态性在PCa风险中的作用。截至2017年4月1日，通过检索PubMed、谷歌、中国知网和EMBASE，在15篇文章中确定了16项符合条件的研究，涉及6301例病例和6510例对照。我们的结果显示，在纯合子模型下，rs1800896多态性与PCa风险降低相关。按种族进行的亚组分析显示，rs1800896多态性降低了白种人中PCa的风险。总之，IL-10基因rs1800896多态性与PCa风险降低相关。需要开展更多涉及更广泛种族人群的研究来证实这些结果。