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壬醛通过环腺苷酸（cAMP）信号通路刺激人毛囊真皮乳头细胞中的生长因子。

Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells.

机构信息

Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea.

出版信息

Int J Mol Sci. 2020 Oct 28;21(21):8054. doi: 10.3390/ijms21218054.

DOI:10.3390/ijms21218054
PMID:33126774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7662673/
Abstract

Human hair follicle dermal papilla cells (DPCs) are a specialized population of cells located in the hair follicles and regulate hair growth and development, particularly by releasing numerous growth factors in response to various physiological conditions. In the present study, we aimed to test whether nonanal, a scent compound from plants, stimulated growth factors in DPCs and to delineate the underlying mechanisms involved. We found that nonanal promoted DPC proliferation in a dose-dependent manner. Meanwhile, it also increased the intracellular cyclic adenosine monophosphate (cAMP) levels and the expression of various growth factor genes such as vascular endothelial growth factor, keratinocyte growth factor, and insulin-like growth factor 1. Furthermore, nonanal treatment stimulated DPC migration. Notably, the benefits of nonanal use were abrogated by cAMP inhibition. Our results reveal the potential of nonanal in preventing hair loss and suggest that its effects are cAMP-mediated in DPCs.

摘要

人毛囊真皮乳头细胞（DPC）是一种位于毛囊中的特化细胞群体，调节毛发的生长和发育，特别是通过响应各种生理条件释放许多生长因子。在本研究中，我们旨在测试植物散发的气味化合物壬醛是否刺激 DPC 中的生长因子，并阐明涉及的潜在机制。我们发现壬醛以剂量依赖的方式促进 DPC 增殖。同时，它还增加了细胞内环腺苷酸（cAMP）水平和各种生长因子基因的表达，如血管内皮生长因子、角质形成细胞生长因子和胰岛素样生长因子 1。此外，壬醛处理刺激了 DPC 的迁移。值得注意的是，cAMP 抑制消除了壬醛的益处。我们的结果揭示了壬醛在预防脱发方面的潜力，并表明其在 DPC 中的作用是 cAMP 介导的。

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