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纤维肌痛综合征患者的成人注意力缺陷多动障碍:评估与残疾情况

Adult attention deficit hyperactivity disorder in patients with fibromyalgia syndrome: Assessment and disabilities.

作者信息

Pallanti Stefano, Porta Francesco, Salerno Luana

机构信息

INS, Istituto di Neuroscienze, Florence, Italy; Albert Einstein College of Medicine (New York), Department of Psychiatry and Behavioral Sciences, USA.

INS, Istituto di Neuroscienze, Florence, Italy; MedCare, Pistoia, Italy.

出版信息

J Psychiatr Res. 2021 Apr;136:537-542. doi: 10.1016/j.jpsychires.2020.10.027. Epub 2020 Oct 24.

Abstract

In the broader list of cognitive concerns, neuropsychological testing has shown that attentional impairment may have a specific burden in Fibromyalgia Syndrome (FMS). Preliminary observations have reported a subset of FMS patient screened for attention disorders fulfilling the actual diagnosis of ADHD, a neurodevelopmental disorder characterized by developmentally inadequate levels of inattention, hyperactivity and impulsivity that might persist in adulthood. Yet, no study to date has systematically examined the history and the specific contribution of ADHD to FMS in terms of clinical impact and related specific disabilities. In this study, 106 individuals with a FMS diagnosis based on the 2010 criteria of the American College of Rheumatology have been assessed for (a) the presence of ADHD; (b) the burden of disability caused by ADHD versus FMS; (c) the presence of other psychiatric disorders. Results indicated that ADHD was present in 24.5% of FMS individuals, it was associated with higher FMS symptoms severity and a greater functional impairment, particularly in the work/school domain. Moreover, patients with both FMS and ADHD had higher frequency of substance use disorders than those with FMS only (38.5% versus 3.8%) and mainly opioids. Overall, results suggest that ADHD can increase burden adding specific disability in work and social activities, and it is associated with a trend for the excessive use of opioid painkillers. Detection of neurodevelopmental and actual symptoms of ADHD is highly recommended especially in patient prone to increase the dose of anti-pain medication.

摘要

在更广泛的认知问题清单中,神经心理学测试表明,注意力损害在纤维肌痛综合征(FMS)中可能具有特定的负担。初步观察报告称,一部分接受注意力障碍筛查的FMS患者符合注意缺陷多动障碍(ADHD)的实际诊断标准,ADHD是一种神经发育障碍,其特征是注意力不集中、多动和冲动水平在发育上不足,且可能持续到成年期。然而,迄今为止,尚无研究系统地研究ADHD对FMS的病史、临床影响及相关特定残疾方面的具体贡献。在本研究中,对106名根据美国风湿病学会2010年标准诊断为FMS的个体进行了评估,以确定:(a)是否存在ADHD;(b)ADHD与FMS所导致的残疾负担;(c)是否存在其他精神障碍。结果表明,24.5%的FMS个体存在ADHD,其与更高的FMS症状严重程度和更大的功能损害相关,尤其是在工作/学校领域。此外,同时患有FMS和ADHD的患者物质使用障碍的发生率高于仅患有FMS的患者(38.5%对3.8%),且主要是阿片类药物。总体而言,结果表明ADHD会增加负担,在工作和社交活动中增加特定残疾,并且与阿片类止痛药过度使用的趋势相关。强烈建议检测ADHD的神经发育及实际症状,尤其是在易于增加抗疼痛药物剂量的患者中。

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