Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.
Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, USA.
BMC Musculoskelet Disord. 2020 Oct 31;21(1):711. doi: 10.1186/s12891-020-03733-0.
Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture.
We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data.
Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake (1.76-14.30 mg/day), the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51-0.82; heterogeneity: P = 0.66, I = 0.00%) and 0.63 (95%CrI: 0.44-0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14-0.96) for case-control studies and 0.82 (95% CrI: 0.58-0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28-0.89), 0.86 (95% CrI: 0.35-0.1.37), and 0.91(95% CrI: 0.75-1.00) for studies conducted in China, the United States, and Europe, respectively. By sex, the pooled RRs were 0.88 (95% CrI: 0.73-0.99) for males and 0.76 (95% CrI, 0.44-1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%.
The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship.
研究 β-胡萝卜素摄入量与骨折风险之间关联的流行病学研究结果不一致。我们进行了一项荟萃分析，以调查 β-胡萝卜素摄入量与骨折风险之间的关系。
我们系统地检索了 PubMed、EMBASE 和 Cochrane 图书馆数据库，以获取截至 2019 年 12 月发表的相关文章。我们还从临床数据库中确定的文章的参考文献列表中识别研究。使用固定效应模型和贝叶斯随机效应模型来综合数据。
共有 9 项研究纳入了本荟萃分析，共纳入了 190545 名男性和女性，平均年龄为 59.8 岁。对于 β-胡萝卜素摄入量（1.76-14.30mg/天），任何部位骨折的汇总风险比（RR）为 0.67（95%可信区间（CrI）：0.51-0.82；异质性：P=0.66，I=0.00%）和髋部骨折的 0.63（95%CrI：0.44-0.82）。按研究设计，病例对照研究的汇总 RR 为 0.55（95%CrI：0.14-0.96），队列研究的汇总 RR 为 0.82（95%CrI：0.58-0.99）。按地理区域，汇总 RR 分别为中国研究的 0.58（95%CrI：0.28-0.89）、美国研究的 0.86（95%CrI：0.35-0.137）和欧洲研究的 0.91（95%CrI：0.75-1.00）。按性别，男性的汇总 RR 为 0.88（95%CrI：0.73-0.99），女性的汇总 RR 为 0.76（95%CrI，0.44-1.07）。β-胡萝卜素摄入量降低髋部骨折和任何类型骨折风险超过 20%的可能性为 95%。
本荟萃分析表明，β-胡萝卜素摄入量与骨折风险呈负相关，这在病例对照和队列研究中均得到一致观察。需要进行随机对照试验来证实这种关系。
