Department of Psychology, Faculty of Human Sciences, Lorestan University, Khorramabad, Iran.
BMC Psychol. 2020 Oct 31;8(1):114. doi: 10.1186/s40359-020-00480-8.
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. MS is significantly associated with a high rate of psychological, behavioral, and emotional consequences. Despite the frequent mental disorders, high rate of psychological comorbidities, and emotional problems in people with MS (PwMS), these conditions are often underdiagnosed and undertreated. This study aimed to examine the efficacy of a group format of the unified protocol for the transdiagnostic treatment of emotional disorders in adult PwMS associated with an emotional disorder.
Seventy adult PwMS were randomized using an internet-based computer system to either the unified protocol (n = 35) or treatment as usual condition. The assessment protocol included semi-structured clinical interviews and self-reports evaluating diagnostic criteria, depression, anxiety and worry symptoms, emotional dysregulation, and affectivity.
The parametric test of analysis of covariance, followed the intent to treat analyses, revealed the unified protocol significantly changed depression symptoms (Cohen's d = 1.9), anxiety symptoms (Cohen's d = 2.16), worry symptoms (Cohen's d = 1.27), emotion dysregulation (Cohen's d = 0.44), positive affect (Cohen's d = 1.51), and negative affect (Cohen's d = 1.89) compared with the control group. The unified protocol also significantly improved outcome scores at the end of treatment relative to baseline (p < .001).
The findings support that the unified protocol could be an additional efficient psychological treatment for PwMS. Trial registration IRCT, number: IRCT20190711044173N1. Registered 31october 2019, https://en.irct.ir/user/trial/40779/view .
多发性硬化症（MS）是一种中枢神经系统的神经退行性疾病。MS 与心理、行为和情绪后果的高发生率显著相关。尽管多发性硬化症患者（PwMS）经常出现精神障碍、高心理共病率和情绪问题，但这些情况往往被漏诊和治疗不足。本研究旨在研究统一方案治疗成年 PwMS 伴情绪障碍的情绪障碍的小组形式的疗效。
使用基于互联网的计算机系统，对 70 名成年 PwMS 进行随机分组，分别为统一方案组（n = 35）或常规治疗组。评估方案包括半结构化临床访谈和自我报告，评估诊断标准、抑郁、焦虑和担忧症状、情绪调节和情感。
协方差分析的参数检验，遵循意向治疗分析，显示统一方案显著改变了抑郁症状（Cohen's d = 1.9）、焦虑症状（Cohen's d = 2.16）、担忧症状（Cohen's d = 1.27）、情绪调节障碍（Cohen's d = 0.44）、积极情绪（Cohen's d = 1.51）和消极情绪（Cohen's d = 1.89）与对照组相比。与基线相比，统一方案在治疗结束时也显著改善了结局评分（p <.001）。
研究结果支持统一方案可能是治疗 PwMS 的另一种有效的心理治疗方法。试验注册号 IRCT，编号：IRCT20190711044173N1。注册于 2019 年 10 月 31 日，https://en.irct.ir/user/trial/40779/view。
