Department of Psychology, Faculty of Human Sciences, Lorestan University, Khorramabad, Iran.
Department of Psychology, Islamic Azad University, Hamadan Branch, Hamadan, Iran.
BMC Womens Health. 2020 Oct 31;20(1):245. doi: 10.1186/s12905-020-01109-z.
Multiple sclerosis (MS) is a chronic, unpredictable, neurodegenerative disease, significantly associated with psychological, behavioral, cognitive, and emotional consequences. MS is more common in females than males and frequently affects women during their reproductive years. Despite the frequent mental disorders, comorbidities, and emotional problems in People with MS (PwMS), these conditions are too often underdiagnosed and undertreated.
This study aimed to examine the efficacy of a group format of the Unified Protocol (UP) for the Transdiagnostic treatment of depression and anxiety disorders in females with MS.
In the present study, Sixty-four adult females diagnosed with MS were randomized to either the UP (n = 32) or treatment-as-usual conditions. The assessment protocol included semi-structured clinical interviews and self-reports evaluating diagnostic criteria, depression, anxiety and worry symptoms, emotional regulation, and affectivity.
Repeated measure analysis of variance (ANOVA) revealed that the UP significantly improved depression scores [Cohen's d = - 2.11, 95% CI (- 2.72, - 1.50)], anxiety scores [Cohen's d = - 3.34, 95% CI (- 4.01, - 2.58)], positive and negative affect scale (PANAS)-positive affect scores [Cohen's d = 1.46, 95% CI (1.46, 2.01)], PANAS-negative affect scores [Coen's d = - 2.21, 95% CI (- 2.84, - 1.60)], difficulties emotion regulation scale scores [Cohen's d = 1.40, 95% CI (- 0.87, - 0.03)], and Worry scale scores [Cohen's d = - 0.45, 95% CI (- 0.95, - 0.04)] at the end of treatment relative to compared to the control condition. Also, treatment gains were maintained at the three-month follow-up (p < 0.001).
The findings provide the support that the UP could be an additional efficient psychological treatment for females with MS. ISRCTN Number: ISRCTN95459505.
多发性硬化症（MS）是一种慢性、不可预测的神经退行性疾病，与心理、行为、认知和情绪后果密切相关。MS 在女性中的发病率高于男性，并且经常在女性的生育期影响她们。尽管多发性硬化症患者（PwMS）经常出现精神障碍、合并症和情绪问题，但这些情况往往被误诊和治疗不足。
本研究旨在检验团体格式的统一方案（UP）对女性多发性硬化症患者共病抑郁和焦虑障碍的治疗效果。
在本研究中，64 名成年女性被诊断为多发性硬化症，随机分为 UP 组（n=32）或常规治疗组。评估方案包括半结构化临床访谈和自我报告，评估诊断标准、抑郁、焦虑和担忧症状、情绪调节和情感。
重复测量方差分析（ANOVA）显示，UP 显著改善了抑郁评分[Cohen's d=-2.11，95%置信区间（-2.72，-1.50）]、焦虑评分[Cohen's d=-3.34，95%置信区间（-4.01，-2.58）]、正性和负性情绪量表（PANAS）-正性情绪评分[Cohen's d=1.46，95%置信区间（1.46，2.01）]、PANAS 负性情绪评分[Cohen's d=-2.21，95%置信区间（-2.84，-1.60）]、情绪调节困难量表评分[Cohen's d=1.40，95%置信区间（-0.87，-0.03）]和担忧量表评分[Cohen's d=-0.45，95%置信区间（-0.95，-0.04）]在治疗结束时相对于对照组。此外，在三个月的随访中（p<0.001），治疗效果得到了维持。
这些发现提供了支持，表明 UP 可能是治疗多发性硬化症女性患者的一种额外有效的心理治疗方法。ISRCTN 编号：ISRCTN82244424。
