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泌乳期大鼠过早断奶对母体肝脏和脂肪组织体内脂肪生成速率的影响:催乳素的潜在调节作用

Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin.

作者信息

Agius L, Robinson A M, Girard J R, Williamson D H

出版信息

Biochem J. 1979 Jun 15;180(3):689-92. doi: 10.1042/bj1800689.

Abstract

Removal of pups for 24 h from rats at peak lactation decreased 3H2O incorporation into lipid in vivo in mammary gland by 95%, whereas it was increased in liver (77%) and adipose tissue (330%). These increases were prevented by administration of prolactin. Plasma insulin increased 3-fold on weaning and this was partially prevented by prolactin.

摘要

在泌乳高峰期将幼崽从大鼠身边移走24小时,会使乳腺中脂质的体内3H2O掺入量减少95%,而肝脏(77%)和脂肪组织(330%)中的掺入量增加。给予催乳素可阻止这些增加。断奶时血浆胰岛素增加了3倍,催乳素可部分阻止这种增加。

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