Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
Semin Cancer Biol. 2021 Aug;73:169-177. doi: 10.1016/j.semcancer.2020.10.007. Epub 2020 Oct 28.
An inverse correlation between high-density lipoprotein cholesterol (HDL-C) and cancer risk has been shown by several epidemiological studies. Some studies have even suggested that HDL-C can be used as a prognostic marker in patients with certain types of cancer. However, whether reduced HDL-C level is a consequential or causal factor in the development and progression of cancer remains a controversial issue. In this review, we update and summarize recent advances that highlight the role of HDL and some of its components in prognosis, diagnosis and treatment of cancer.
多项流行病学研究表明，高密度脂蛋白胆固醇（HDL-C）与癌症风险呈负相关。一些研究甚至表明，HDL-C 可以作为某些类型癌症患者的预后标志物。然而，HDL-C 水平降低是否是癌症发展和进展的因果因素，仍是一个有争议的问题。在这篇综述中，我们更新并总结了最近的进展，强调了 HDL 及其某些成分在癌症预后、诊断和治疗中的作用。
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