Kasik J W, Wan Y J, Ozato K
Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Mol Cell Biol. 1987 Sep;7(9):3349-52. doi: 10.1128/mcb.7.9.3349-3352.1987.
Expression of the c-fos gene during murine perinatal development was studied. Before birth, all eight of the prenatal organs tested expressed undetectable or low levels of c-fos mRNA. On the day of birth, there occurred a 10- to 100-fold increase in the level of c-fos message in all of these organs. The expression was transient, in that 1 day after birth, the level of c-fos mRNA precipitously dropped. The c-fos gene expression at birth is unrelated to the expression of the c-myc gene and major histocompatibility complex class I genes, which display distinct kinetics during the perinatal development. The c-fos gene was also expressed locally and transiently in the gravid uterus 1 to 2 days prior to delivery. These results indicate that an event associated with birth induced c-fos gene expression in the mother and newborn.
研究了c-fos基因在小鼠围产期发育过程中的表达情况。出生前，所检测的八个产前器官均表达不可检测或低水平的c-fos mRNA。在出生当天，所有这些器官中c-fos信息水平出现了10至100倍的增加。这种表达是短暂的，因为出生后1天，c-fos mRNA水平急剧下降。出生时c-fos基因的表达与c-myc基因和主要组织相容性复合体I类基因的表达无关，它们在围产期发育过程中表现出不同的动力学。在分娩前1至2天，c-fos基因也在妊娠子宫中局部且短暂地表达。这些结果表明，与出生相关的一个事件诱导了母亲和新生儿中c-fos基因的表达。
