Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, Malaysia.
Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Expert Rev Anti Infect Ther. 2021 May;19(5):571-586. doi: 10.1080/14787210.2021.1843427. Epub 2020 Dec 8.
Quorum-sensing (QS) is a microbial cell-to-cell communication system that utilizes small signaling molecules to mediates interactions between cross-kingdom microorganisms, including Gram-positive and -negative microbes. QS molecules include N-acyl-homoserine-lactones (AHLs), furanosyl borate, hydroxyl-palmitic acid methylester, and methyl-dodecanoic acid. These signaling molecules maintain the symbiotic relationship between a host and the healthy microbial flora and also control various microbial virulence factors. This manuscript has been developed based on published scientific papers.
Furanones, glycosylated chemicals, heavy metals, and nanomaterials are considered QS inhibitors (QSIs) and are therefore capable of inhibiting the microbial QS system. QSIs are currently being considered as antimicrobial therapeutic options. Currently, the low speed at which new antimicrobial agents are being developed impairs the treatment of drug-resistant infections. Therefore, QSIs are currently being studied as potential interventions targeting QS-signaling molecules and quorum quenching (QQ) enzymes to reduce microbial virulence.
QSIs represent a novel opportunity to combat antimicrobial resistance (AMR). However, no clinical trials have been conducted thus far assessing their efficacy. With the recent advancements in technology and the development of well-designed clinical trials aimed at targeting various components of the, QS system, these agents will undoubtedly provide a useful alternative to treat infectious diseases.
群体感应（QS）是一种微生物细胞间通讯系统，利用小分子信号分子来调节跨菌群微生物（包括革兰氏阳性菌和革兰氏阴性菌）之间的相互作用。QS 分子包括 N-酰基高丝氨酸内酯（AHLs）、呋喃酮、羟基棕榈酸甲酯和十二烷酸甲酯。这些信号分子维持宿主与健康微生物菌群之间的共生关系，同时控制各种微生物毒力因子。本文基于已发表的科学论文编写。
呋喃酮、糖基化化学品、重金属和纳米材料被认为是群体感应抑制剂（QSIs），因此能够抑制微生物 QS 系统。QSIs 目前被认为是具有抗菌治疗作用的选择。目前，新抗菌药物的研发速度缓慢，这影响了耐药感染的治疗。因此，QSIs 目前正在作为针对 QS 信号分子和群体感应淬灭（QQ）酶的潜在干预措施进行研究，以降低微生物的毒力。
QSIs 代表了对抗抗菌药物耐药性（AMR）的新机会。然而，迄今为止，尚未进行临床试验来评估其疗效。随着技术的最新进展和旨在针对 QS 系统各个组成部分的精心设计临床试验的开展，这些药物无疑将为治疗传染病提供有用的替代选择。
