Telekes A, Holland R L, Peck A W
CNS Experimental Therapy Unit, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS U.K.
Pain. 1987 Sep;30(3):321-328. doi: 10.1016/0304-3959(87)90020-0.
The sensitivity of the cold-induced pain (CP) model to the non-steroidal anti-inflammatory drug (NSAID) indomethacin was studied in healthy volunteers. Effects on the central nervous system were also sought. Subjects received single oral doses of indomethacin 50 and 100 mg, dipipanone 8 mg and placebo, according to a double-blind, randomised, balanced, cross-over design with an interval of 7 days between occasions. A test battery was performed before each treatment and then at 45, 105 and 165 min post treatment. Pain scores were unaltered by indomethacin at either dose, but the drug certainly affected the CNS, increasing respiratory drive and changing self-assessed mood. It is concluded that the CP model is insensitive to indomethacin, even in doses which have clear-cut CNS effects. The respiratory stimulant action of indomethacin may deserve further study.
在健康志愿者中研究了冷诱导疼痛（CP）模型对非甾体抗炎药（NSAID）吲哚美辛的敏感性。同时也探寻了其对中枢神经系统的影响。根据双盲、随机、平衡、交叉设计，受试者分别单次口服50毫克和100毫克吲哚美辛、8毫克二苯哌丙酮及安慰剂，每次给药间隔7天。在每次治疗前以及治疗后45、105和165分钟进行一组测试。两种剂量的吲哚美辛均未改变疼痛评分，但该药物确实影响了中枢神经系统，增加了呼吸驱动力并改变了自我评估的情绪。得出的结论是，CP模型对吲哚美辛不敏感，即使是在具有明确中枢神经系统效应的剂量下也是如此。吲哚美辛的呼吸刺激作用可能值得进一步研究。
