Wong Hey Chiann, Ooi Yuxuan, Pulikkotil Shaju Jacob, Naing Cho
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
Institute for Research, Development and Innovation (IRDI), International Medical University, 5700, Kuala Lumpur, Malaysia.
BMC Oral Health. 2018 Oct 22;18(1):171. doi: 10.1186/s12903-018-0637-9.
Periodontitis is a major oral health problem and it is considered as one of the reasons for tooth loss in developing and developed nations. The objective of the current review was to investigate the association between IL10 polymorphisms - 1082 A > G (rs1800896), -819C > T (rs1800871), - 592 A > C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis.
This is a meta- analysis study, following the preferred reporting items for systematic reviews and meta- analyses (PRISMA). Relevant studies were searched in the health related electronic databases. Methodological quality of the included studies were assessed using the Newcastle-Ottawa Scale. For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (- 1082 A > G, -819C > T, - 592 A > C) and the risk of periodontitis. For pooling of the estimates across studies included, the summary OR and its 95% CIs were calculated with random-effects model. The pooled estimates were done under four genetic models such as the allelic contrast model, the recessive model, the dominant model and the additive model. Trial sequential analysis (TSA) was done for estimation of the required information size for this meta-analysis study.
Sixteen studies were identified for this review. The included studies were assessed to be of moderate to good methodological quality. A significant association between polymorphism of IL10-1082 A > G polymorphism and the risk of chronic periodontitis in the non-Asian populations was observed only in the recessive model (OR,1.42; 95% CI:1.11, 1.8,I: 43%). The significant associations between - 592 A > C polymorphism and the risk of aggressive periodontitis in the non-Asian populations were observed in particular genetic models such as allele contrast (OR, 4.34; 95%CI:1.87,10.07,I: 65%) and recessive models (OR, 2.1; 95% CI:1.16, 3.82,I: 0%). The TSA plot revealed that the required information size for evidence of effect was sufficient to draw a conclusion.
This meta-analysis suggested that the IL10-1082 A > G polymorphism was associated with chronic periodontitis CP risk in non-Asians. Thus, in order to further establish the associations between IL10 (- 819 C > T, - 592 A > C) in Asian populations, future studies should include larger sample sizes with multi-ethnic groups.
牙周炎是一个主要的口腔健康问题，在发展中国家和发达国家，它都被视为牙齿缺失的原因之一。本综述的目的是研究白细胞介素10（IL10）基因多态性-1082 A>G（rs1800896）、-819C>T（rs1800871）、-592 A>C（rs1800872）与慢性牙周炎或侵袭性牙周炎风险之间的关联。
这是一项遵循系统评价和荟萃分析首选报告项目（PRISMA）的荟萃分析研究。在与健康相关的电子数据库中检索相关研究。使用纽卡斯尔-渥太华量表评估纳入研究的方法学质量。对于各个研究，计算比值比（OR）及其95%置信区间（CI），以评估IL10基因多态性（-1082 A>G、-819C>T、-592 A>C）与牙周炎风险之间的关联强度。对于纳入研究的估计值合并，采用随机效应模型计算汇总OR及其95%CI。汇总估计在四种遗传模型下进行，如等位基因对比模型、隐性模型、显性模型和加性模型。进行试验序贯分析（TSA）以估计本荟萃分析研究所需的信息量。
本综述共纳入16项研究。纳入研究的方法学质量评估为中等至良好。仅在隐性模型中观察到IL10 -1082 A>G多态性与非亚洲人群慢性牙周炎风险之间存在显著关联（OR，1.42；95%CI：1.11，1.8；I：43%）。在特定遗传模型中，如等位基因对比模型（OR，4.34；95%CI：1.87，10.07；I：65%）和隐性模型（OR，2.1；95%CI：1.16，3.82；I：0%）中，观察到-592 A>C多态性与非亚洲人群侵袭性牙周炎风险之间存在显著关联。TSA图显示效应证据所需的信息量足以得出结论。
本荟萃分析表明，IL10 -1082 A>G多态性与非亚洲人慢性牙周炎（CP）风险相关。因此，为了进一步确定亚洲人群中IL10（-819 C>T，-592 A>C）之间的关联，未来的研究应纳入更大样本量的多民族群体。
