Ocak Ibrahim, Topsakal Vedat, Van de Heyning Paul, Van Haesendonck Gilles, Jorissen Cathérine, van de Berg Raymond, Vanderveken Olivier M, Van Rompaey Vincent
Department Otorhinolaryngology & Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium.
Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Front Neurol. 2020 Oct 8;11:552495. doi: 10.3389/fneur.2020.552495. eCollection 2020.
Superior canal dehiscence syndrome (SCDS) is a condition characterized by a defect in the bone overlying the superior semicircular canal, creating a third mobile window into the inner ear. Patients can experience disabling symptoms and opt for surgical management. Limited data are available on the impact of SCDS on health-related quality of life (HRQoL) and disease-specific HRQoL more specifically. To perform a prospective analysis on generic HRQoL in SCDS patients compared to healthy age-matched controls. A prospective study was performed on patients diagnosed with SCDS and who did not undergo reconstructive surgery yet. Patients were recruited between November 2017 and January 2020 and asked to complete the Health Utility Index (HUI) Mark 2 (HUI2)/Mark 3 (HUI3) questionnaire. For the control group, age-matched participants without otovestibular pathology or other chronic pathology were recruited. The multi-attribute utility function (MAUF) score was calculated for the HUI2 and HUI3. Results of both groups were compared using the Mann-Whitney U test. A total of 20 patients completed the questionnaire. Age ranged from 37 to 79 years with a mean age of 56 years (45% males and 55% females). The control group consisted of 20 participants with a mean age of 56.4 years and ranged from 37 to 82 years (35% males and 65% females). For the case group, median HUI2 MAUF score was 0.75 and median HUI3 MAUF score was 0.65. For the control group, the median scores were 0.88 and 0.86 respectively. There was a statistically significant difference for both HUI2 ( = 0.024) and HUI3 ( = 0.011). SCDS patients had a worse generic HRQoL than age-matched healthy controls. One patient with unilateral SCDS had a negative HUI3 MAUF score (-0.07), indicating a health-state worse than death. SCDS patients have significantly lower health utility values than an age-matched control group. This confirms the negative impact of SCDS on generic HRQoL, even when using an instrument that is not designed to be disease-specific but to assess health state in general. These data can be useful to compare impact on HRQoL among diseases.
上半规管裂综合征（SCDS）是一种以上半规管上方骨质缺损为特征的疾病，在内耳形成了第三个活动窗。患者可能会出现致残症状并选择手术治疗。关于SCDS对健康相关生活质量（HRQoL）尤其是疾病特异性HRQoL的影响，现有数据有限。对SCDS患者与年龄匹配的健康对照者的一般HRQoL进行前瞻性分析。对诊断为SCDS且尚未接受重建手术的患者进行了一项前瞻性研究。在2017年11月至2020年1月期间招募患者，并要求他们完成健康效用指数（HUI）Mark 2（HUI2）/Mark 3（HUI3）问卷。对于对照组，招募了没有耳前庭病变或其他慢性病变的年龄匹配参与者。计算HUI2和HUI3的多属性效用函数（MAUF）得分。使用曼-惠特尼U检验比较两组结果。共有20名患者完成了问卷。年龄范围为37至79岁，平均年龄为56岁（男性占45%，女性占55%）。对照组由20名参与者组成，平均年龄为56.4岁，年龄范围为37至82岁（男性占35%，女性占65%）。对于病例组，HUI2的MAUF中位数得分是0.75，HUI3的MAUF中位数得分是0.65。对于对照组，中位数得分分别为0.88和0.86。HUI2（ = 0.024）和HUI3（ = 0.011）均有统计学显著差异。SCDS患者的一般HRQoL比年龄匹配的健康对照者差。一名单侧SCDS患者的HUI3 MAUF得分为负数（-0.07），表明其健康状态比死亡还差。SCDS患者的健康效用值明显低于年龄匹配的对照组。这证实了SCDS对一般HRQoL的负面影响，即使使用的工具并非专门针对该疾病设计，而是用于总体评估健康状态。这些数据对于比较不同疾病对HRQoL的影响可能有用。
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