Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Department of General Dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2020 Oct 2;11:543623. doi: 10.3389/fendo.2020.543623. eCollection 2020.
Bone regeneration has become a research hotspot and therapeutic target in the field of bone and joint medicine. Stem cell-based therapy aims to promote endogenous regeneration and improves therapeutic effects and side-effects of traditional reconstruction of significant bone defects and disorders. Human amniotic mesenchymal stem cells (hAMSCs) are seed cells with superior paracrine functions on immune-regulation, anti-inflammation, and vascularized tissue regeneration. The present review summarized the source and characteristics of hAMSCs and analyzed their roles in tissue regeneration. Next, the therapeutic effects and mechanisms of hAMSCs in promoting bone regeneration of joint diseases and bone defects. Finally, the clinical application of hAMSCs from current clinical trials was analyzed. Although more studies are needed to confirm that hAMSC-based therapy to treat bone diseases, the clinical application prospect of the approach is worth investigating.
骨再生已成为骨与关节医学领域的研究热点和治疗靶点。基于干细胞的治疗旨在促进内源性再生，改善传统重建对重大骨缺损和疾病的治疗效果和副作用。人羊膜间充质干细胞（hAMSCs）是一种具有优异旁分泌功能的种子细胞，可调节免疫、抗炎和血管化组织再生。本综述总结了 hAMSCs 的来源和特性，并分析了其在组织再生中的作用。接下来，分析了 hAMSCs 在促进关节疾病和骨缺损骨再生中的治疗效果和机制。最后，分析了当前临床试验中 hAMSCs 的临床应用。尽管还需要更多的研究来证实基于 hAMSC 的治疗方法可用于治疗骨疾病，但该方法的临床应用前景值得研究。
