Iaquinta Maria Rosa, Mazzoni Elisa, Bononi Ilaria, Rotondo John Charles, Mazziotta Chiara, Montesi Monica, Sprio Simone, Tampieri Anna, Tognon Mauro, Martini Fernanda
Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Institute of Science and Technology for Ceramics, National Research Council, Faenza, Italy.
Front Cell Dev Biol. 2019 Nov 12;7:268. doi: 10.3389/fcell.2019.00268. eCollection 2019.
The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed.
由创伤、骨质疏松症或肿瘤导致的骨折再生，是我们这个超老龄化社会中的一个重大问题。骨再生是再生医学中主要关注的课题之一。近年来，干细胞因其自我更新和分化能力而被应用于再生医学，并取得了有趣的成果。此外，干细胞能够分泌生物活性分子并调节不同宿主组织中其他细胞的行为。使用干细胞时，骨再生过程可能会有效且快速地改善。为此，干细胞常与生物材料/支架和生长因子一起使用，以加速骨折部位的骨愈合。简而言之，本综述将描述骨结构以及干细胞的成骨分化。此外，还将讨论间充质干细胞在组织工程领域中对骨修复/再生的作用及其在临床应用中的最新进展。
