Ye Zhi-Ning, Xia Harry Hua-Xiang, Zhang Ran, Li Lan, Wu Li-Hao, Liu Xu-Juan, Xie Wen-Rui, He Xing-Xiang
Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China.
Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China.
Gastroenterol Res Pract. 2020 Oct 19;2020:8825189. doi: 10.1155/2020/8825189. eCollection 2020.
The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on eradication.
Consecutive patients who had been treated with WMT for various indications and who were positive for infection before WMT treatment but had never received eradication therapy for infection were invited to take a follow-up C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined.
A total of 32 eligible patients were included, and the overall eradication rate was 40.6% (13/32). Patients with eradication had a higher pepsinogen ratio (PGR) than those without (13.00 ± 6.978.31 ± 3.733; = 0.02). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% 31.58%; = 0.208). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of infection (58.33% vs 16.67%; = 0.152). There was no significant difference in other demographic and clinical factors between patients with and without eradication.
infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials.
通过洗涤制备的粪便微生物群移植最近被称为洗涤微生物群移植（WMT）。本前瞻性研究旨在探讨WMT根除幽门螺杆菌（Hp）的可行性和疗效。
连续入选因各种适应证接受WMT治疗、WMT治疗前Hp感染阳性但从未接受过Hp感染根除治疗的患者，进行随访C尿素呼气试验。确定人口统计学、临床因素以及胃功能和肠屏障功能的实验室指标与治疗效果的相关性。
共纳入32例符合条件的患者，总体Hp根除率为40.6%（13/32）。Hp根除患者的胃蛋白酶原比值（PGR）高于未根除患者（13.00±6.97对8.31±3.733；P = 0.02）。女性患者的根除率高于男性患者，尽管差异无统计学意义（53.85%对31.58%；P = 0.208）。与下消化道给药途径相比，中消化道给药途径似乎更适合治疗Hp感染（58.33%对16.67%；P = 0.152）。根除和未根除Hp的患者在其他人口统计学和临床因素方面无显著差异。
部分接受WMT的患者Hp感染得到根除。WMT前PGR升高似乎与治疗效果相关。需要进一步研究以证实WMT的疗效，特别是在随机对照试验中与目前推荐方案联合使用时。
