Girawan Dolvy, Judistiani Raden T D, Risan Nelly A, Bestari Muhammad B, Nugraha Eka S, Ermaya Yudith S, Prasetyo Dwi
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, Indonesia.
Centre of Immunology Studies, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
Int J Hepatol. 2020 Oct 19;2020:3414869. doi: 10.1155/2020/3414869. eCollection 2020.
Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. However, after three decades, the HBV infection prevalence stays stagnant. This study aimed to explore the seroprevalence of HBV markers and the attributable risk factors of pregnant women at risk of transmitting HBV to their offspring.
A cross-sectional study was conducted on pregnant women from primary midwifery and obstetric clinics across Bandung, Indonesia, to assess the HBsAg, anti-HBc, and anti-HBs serological markers. Questionnaire-based interviews were used to obtain the sociodemographic determinants. Logistic regression was applied to assess the association of each determinant factor to positive HBsAg or negative anti-HBs as a dependent variable, which was then reported as odds ratios (OR).
A total of 196 subjects were recruited with 12/196 (6.1%) of them were positive HBsAg. After exclusions of those with positive HBsAg and anti-HBc, 24/175 (13.7%) women were isolated as positive anti-HBs, leaving 151/175 (86.3%) women with negative anti-HBs who were susceptible to HBV infection. Low body mass index (BMI) less than 18.5 kg/m was a risk factor for positive HBsAg with OR = 5.850 (95% CI 1.466-23.34), = 0.012. Nevertheless, no significant determinant factor was associated with negative anti-HBs.
Most pregnant women in Bandung, Indonesia, are susceptible to HBV infection, as marked by the negative anti-HBs status.
乙型肝炎病毒（HBV）感染是一种给全球带来沉重负担的疾病，约占世界总人口的3.5%。该疾病的主要传播途径是母婴传播（MTCT）。印度尼西亚于1987年就已启动乙肝疫苗接种计划。然而，三十年后，HBV感染率仍停滞不前。本研究旨在探讨乙肝病毒标志物的血清流行率以及有将HBV传播给后代风险的孕妇的归因风险因素。
在印度尼西亚万隆的初级助产和产科诊所对孕妇进行了一项横断面研究，以评估乙肝表面抗原（HBsAg）、乙肝核心抗体（anti-HBc）和乙肝表面抗体（anti-HBs）血清学标志物。采用基于问卷的访谈来获取社会人口学决定因素。应用逻辑回归分析，以阳性HBsAg或阴性anti-HBs作为因变量，评估每个决定因素的关联，结果以比值比（OR）报告。
共招募了196名受试者，其中12/196（6.1%）为HBsAg阳性。排除HBsAg和anti-HBc阳性者后，24/175（13.7%）的女性被分离为anti-HBs阳性，其余151/175（86.3%）的女性anti-HBs阴性，易感染HBV。低体重指数（BMI）低于18.5kg/m是HBsAg阳性的一个风险因素，OR = 5.850（95%CI 1.466 - 23.34），P = 0.012。然而，没有显著的决定因素与anti-HBs阴性相关。
印度尼西亚万隆的大多数孕妇易感染HBV，表现为anti-HBs状态阴性。
