Kori Mayuko, Awano Nobuyasu, Inomata Minoru, Kuse Naoyuki, Tone Mari, Yoshimura Hanako, Jo Tatsunori, Takada Kohei, Tanaka Atsuko, Mawatari Momoko, Ueda Akihiro, Izumo Takehiro
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Tokyo, Japan.
Department of Infectious Disease, Japanese Red Cross Medical Center, Tokyo, Japan.
Respir Med Case Rep. 2020 Oct 12;31:101246. doi: 10.1016/j.rmcr.2020.101246. eCollection 2020.
In 2014, an autochthonous dengue fever outbreak occurred around the Yoyogi Park in Japan for the first time in 70 years. Despite no local cases reported since then, the risk of another outbreak remains high. This study reviews the autochthonous dengue fever cases of the outbreak, investigates its causes, and delineates preventive measures against autochthonous dengue epidemics.
We conducted a case series study of 15 patients who visited our institution during the 2014 outbreak. We collected and evaluated data on the surveillance of vector mosquitoes, weather, pest control, travelers' origins and destinations, and imported dengue fever cases using reports made by public institutions.
All patients recovered with supportive treatments and none met the diagnostic criteria for severe dengue infection. Twelve patients with positive real-time polymerase chain reactions were confirmed as having dengue virus-1 infections. We found no obvious associations between the number of mosquitoes and the weather, or between the number of imported dengue fever cases and that of travelers. Insect growth regulator (IGR) against vector mosquitoes has been used since 2014 for pest control, but the number of larvae has not declined in the Yoyogi Park, although that of imagoes has been relatively suppressed.
The 2014 outbreak emerged without particularly favorable climate conditions for vector mosquitoes. We found no obvious associations between the number of travelers or the imported dengue fever cases and the outbreak, but the increasing number of travelers may contribute to another outbreak. Pest control, including IGR, remains essential for infection control.
2014年，日本代代木公园周边70年来首次发生本土登革热疫情。尽管此后未报告本地病例，但再次爆发疫情的风险仍然很高。本研究回顾了此次疫情中的本土登革热病例，调查其成因，并阐述针对本土登革热流行的预防措施。
我们对2014年疫情期间到我院就诊的15例患者进行了病例系列研究。我们利用公共机构提供的报告，收集并评估了有关媒介蚊虫监测、天气、虫害控制、旅行者的出发地和目的地以及输入性登革热病例的数据。
所有患者经支持治疗后康复，无一例符合重症登革热感染的诊断标准。12例实时聚合酶链反应呈阳性的患者被确诊为感染登革病毒-1。我们发现蚊虫数量与天气之间、输入性登革热病例数与旅行者数量之间均无明显关联。自2014年起使用昆虫生长调节剂（IGR）防治媒介蚊虫，但代代木公园的幼虫数量并未下降，尽管成虫数量得到了相对抑制。
2014年的疫情在没有特别有利于媒介蚊虫生长的气候条件下爆发。我们发现旅行者数量或输入性登革热病例数与此次疫情之间无明显关联，但旅行者数量的增加可能导致再次爆发疫情。包括IGR在内的虫害控制对于感染控制仍然至关重要。
