Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA.
Biomed Res Int. 2020 Oct 24;2020:7605453. doi: 10.1155/2020/7605453. eCollection 2020.
To estimate the prevalence rate of ocular symptoms and the positive rate of conjunctival swab samples of patients diagnosed with 2019 Novel Coronavirus Disease (COVID-19).
We performed a systematic review and meta-analysis. A comprehensive literature search was done based on PubMed, Embase, MedRxiv, and the Cochrane Library. The primary outcomes are the prevalence rate of conjunctivitis/conjunctival congestion and the positive rate of conjunctival swab samples. Rates were expressed as proportions with 95% confidence intervals (CIs).
A total of 12 studies with 1930 participants were included for meta-analysis. The pooled prevalence rate of conjunctivitis/conjunctival congestion was 8% (95% CI: 5%-12%). 1% (95% CI: 1%-4%) of COVID-19 patients were diagnosed with conjunctivitis/conjunctival congestion as the initial symptom. The pooled positive rate of conjunctival swab samples was 3% (95% CI: 2%-5%). We also assessed other ocular symptoms reported in the 12 studies, including foreign body sensation, increased secretion, and eye itching. The pooled prevalence rates were 6% (95% CI: 3%-10%), 10% (95% CI: 8%-12%), and 9% (95% CI: 7%-10%), respectively.
The evidence on the positive rate of conjunctival swab samples and the prevalence rates of ocular symptoms indicated that COVID-19 ocular transmission was possible but less likely.
估计新型冠状病毒病（COVID-19）患者眼部症状的患病率和结膜拭子样本的阳性率。
我们进行了系统评价和荟萃分析。根据 PubMed、Embase、MedRxiv 和 Cochrane Library 进行了全面的文献检索。主要结局是结膜炎/结膜充血的患病率和结膜拭子样本的阳性率。用 95%置信区间（CI）表示率的比例。
共纳入 12 项研究，共 1930 名参与者进行荟萃分析。结膜炎/结膜充血的总患病率为 8%（95%CI：5%-12%）。1%（95%CI：1%-4%）的 COVID-19 患者以结膜炎/结膜充血为首发症状。结膜拭子样本的总阳性率为 3%（95%CI：2%-5%）。我们还评估了 12 项研究中报告的其他眼部症状，包括异物感、分泌物增加和眼痒。其总患病率分别为 6%（95%CI：3%-10%）、10%（95%CI：8%-12%）和 9%（95%CI：7%-10%）。
结膜拭子样本的阳性率和眼部症状的患病率表明 COVID-19 可能通过眼部传播，但不太可能。
