• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

病例报告：通过红细胞单采术以及克林霉素、阿奇霉素和阿托伐醌三联疗法迅速成功治疗严重寄生虫血症

Case Report: Overwhelming Parasitemia Successfully Treated Promptly With RBC Apheresis and Triple Therapy With Clindamycin, Azithromycin, and Atovaquone.

作者信息

Li Yijia, Stanley Susan, Villalba Julian A, Nelson Sandra, Gelfand Jeffrey

机构信息

Infectious Diseases Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

Division of Infectious Diseases Brigham and Women's Hospital, Boston, Massachusetts, USA.

出版信息

Open Forum Infect Dis. 2020 Sep 23;7(10):ofaa448. doi: 10.1093/ofid/ofaa448. eCollection 2020 Oct.

DOI:10.1093/ofid/ofaa448
PMID:33134419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7585322/
Abstract

Babesiosis with high-grade parasitemia is life-threatening, especially in asplenic hosts. We report an asplenic patient with parasitemia >50% who was successfully treated with prompt red blood cell apheresis and triple therapy with clindamycin + azithromycin + atovaquone. This regimen may be an alternative to poorly tolerated clindamycin + quinine in severe cases.

摘要

伴有高等级寄生虫血症的巴贝斯虫病会危及生命，在无脾宿主中尤其如此。我们报告了一名寄生虫血症>50%的无脾患者，该患者通过及时进行红细胞单采术以及克林霉素+阿奇霉素+阿托伐醌三联疗法成功治愈。在严重病例中，该治疗方案可能是耐受性差的克林霉素+奎宁的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8011/7585322/cde3612660dd/ofaa448_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8011/7585322/cde3612660dd/ofaa448_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8011/7585322/cde3612660dd/ofaa448_fig1.jpg

相似文献

1
Case Report: Overwhelming Parasitemia Successfully Treated Promptly With RBC Apheresis and Triple Therapy With Clindamycin, Azithromycin, and Atovaquone.病例报告：通过红细胞单采术以及克林霉素、阿奇霉素和阿托伐醌三联疗法迅速成功治疗严重寄生虫血症
Open Forum Infect Dis. 2020 Sep 23;7(10):ofaa448. doi: 10.1093/ofid/ofaa448. eCollection 2020 Oct.
2
Atovaquone and azithromycin for the treatment of babesiosis.阿托伐醌和阿奇霉素用于治疗巴贝斯虫病。
N Engl J Med. 2000 Nov 16;343(20):1454-8. doi: 10.1056/NEJM200011163432004.
3
Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection.免疫功能低下的微小巴贝斯虫感染患者对阿奇霉素-阿托伐醌耐药的出现。
Clin Infect Dis. 2010 Feb 1;50(3):381-6. doi: 10.1086/649859.
4
Atovaquone in the treatment of Babesia microti infections in hamsters.阿托伐醌治疗仓鼠微小巴贝斯虫感染
Am J Trop Med Hyg. 1996 Aug;55(2):219-22. doi: 10.4269/ajtmh.1996.55.219.
5
Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.艾滋病病毒感染患者使用阿托伐醌-氯胍治疗难治性微小巴贝斯虫感染：病例报告
Clin Infect Dis. 2007 Dec 15;45(12):1588-90. doi: 10.1086/523731.
6
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone.长岛的巴贝斯虫病：62例病例回顾，重点关注阿奇霉素和阿托伐醌的治疗
Ann Clin Microbiol Antimicrob. 2017 Apr 11;16(1):26. doi: 10.1186/s12941-017-0198-9.
7
Therapeutic apheresis for babesiosis.巴贝斯虫病的治疗性血液成分单采术
J Clin Apher. 1998;13(1):32-6. doi: 10.1002/(sici)1098-1101(1998)13:1<32::aid-jca7>3.0.co;2-a.
8
Fulminant babesiosis treated with clindamycin, quinine, and whole-blood exchange transfusion.用克林霉素、奎宁和全血置换输血治疗的暴发性巴贝斯虫病。
Transfusion. 2000 Mar;40(3):375-80. doi: 10.1046/j.1537-2995.2000.40030375.x.
9
Atovaquone and azithromycin treatment for babesiosis in an infant.阿托伐醌和阿奇霉素治疗婴儿巴贝斯虫病
Pediatr Infect Dis J. 2007 Feb;26(2):181-3. doi: 10.1097/01.inf.0000250622.11505.8f.
10
Babesiosis in humans: a treatment review.人类巴贝斯虫病：治疗综述
Expert Opin Pharmacother. 2002 Aug;3(8):1109-15. doi: 10.1517/14656566.3.8.1109.

引用本文的文献

1
Relapsing Babesiosis With Molecular Evidence of Resistance to Certain Antimicrobials Commonly Used to Treat Infections.复发性巴贝斯虫病，伴有对某些常用于治疗感染的抗菌药物耐药的分子证据。
Open Forum Infect Dis. 2023 Jul 20;10(8):ofad391. doi: 10.1093/ofid/ofad391. eCollection 2023 Aug.
2
Treatment of Human Babesiosis: Then and Now.人类巴贝斯虫病的治疗：过去与现在
Pathogens. 2021 Sep 1;10(9):1120. doi: 10.3390/pathogens10091120.

本文引用的文献

1
Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo.青蒿琥酯联合用药和他非诺喹对牛巴贝斯虫的体外活性和微小巴贝斯虫的体内活性。
Parasit Vectors. 2020 Jul 20;13(1):362. doi: 10.1186/s13071-020-04235-7.
2
Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts.氯法齐明，一种治疗严重免疫功能低下宿主巴贝虫感染的有前景的药物。
J Infect Dis. 2020 Aug 17;222(6):1027-1036. doi: 10.1093/infdis/jiaa195.
3
Repeat exchange transfusion for treatment of severe babesiosis.
重复换血疗法治疗重症巴贝斯虫病。
Transfus Apher Sci. 2019 Oct;58(5):638-640. doi: 10.1016/j.transci.2019.07.010. Epub 2019 Sep 5.
4
Could the Drug Tafenoquine Revolutionize Treatment of Babesia microti Infection?泰法诺喹能否彻底改变巴贝虫病的治疗方法？
J Infect Dis. 2019 Jul 2;220(3):442-447. doi: 10.1093/infdis/jiz119.
5
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone.长岛的巴贝斯虫病：62例病例回顾，重点关注阿奇霉素和阿托伐醌的治疗
Ann Clin Microbiol Antimicrob. 2017 Apr 11;16(1):26. doi: 10.1186/s12941-017-0198-9.
6
Babesia parasitemia rebound after red blood cell exchange.红细胞置换后巴贝斯虫血症复发。
J Clin Apher. 2017 Aug;32(4):276-278. doi: 10.1002/jca.21492. Epub 2016 Sep 1.
7
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.莱姆病、人粒细胞无形体病和巴贝斯虫病的临床评估、治疗及预防：美国传染病学会临床实践指南
Clin Infect Dis. 2006 Nov 1;43(9):1089-134. doi: 10.1086/508667. Epub 2006 Oct 2.
8
Atovaquone and azithromycin for the treatment of babesiosis.阿托伐醌和阿奇霉素用于治疗巴贝斯虫病。
N Engl J Med. 2000 Nov 16;343(20):1454-8. doi: 10.1056/NEJM200011163432004.
9
Efficacy of azithromycin for treating Babesia microti infection in the hamster model.阿奇霉素治疗仓鼠模型微小巴贝斯虫感染的疗效。
J Infect Dis. 1993 Nov;168(5):1289-92. doi: 10.1093/infdis/168.5.1289.
10
Successful chemotherapy of transfusion babesiosis.输血传播巴贝斯虫病的成功化疗
Ann Intern Med. 1982 May;96(5):601-4. doi: 10.7326/0003-4819-96-5-601.