Lucas F, Bellisle F, Di Maio A
Laboratoire de Neurobiologie de la Nutrition, Collège de France, Paris.
Physiol Behav. 1987;40(5):631-6. doi: 10.1016/0031-9384(87)90109-0.
Insulin secretion occurs in response to cephalic stimulation by foods; in humans, the response is quite variable and its importance in meal situations is difficult to assess. Insulinemia also varies spontaneously in the absence of food stimulation. In the present work, a comparative study of spontaneous and food-associated insulinemia changes was performed. Spontaneous preprandial fluctuations of glycemia and insulinemia were recorded and the presence of significant oscillations or trends was investigated. Premeal changes in insulinemia then served as a basis for evaluating the preabsorptive insulin response (PIR) during food ingestion. A sinewave fitted to preprandial insulin oscillations did not appear satisfactory as a basis for the assessment of the PIR. Significant PIRs were then defined in terms of deviation from a confidence interval (mean of the preprandial values +/- 2 SD). Significant PIRs were more frequent when the food presented was more palatable. Individual differences in responsiveness appeared. The physiological significance of a PIR over a background of spontaneous fluctuations is discussed.
胰岛素分泌是对食物的头部刺激作出的反应；在人类中，这种反应变化很大，其在进餐情况下的重要性难以评估。在没有食物刺激的情况下，胰岛素血症也会自发变化。在本研究中，对自发的和与食物相关的胰岛素血症变化进行了比较研究。记录了餐前血糖和胰岛素血症的自发波动，并研究了显著振荡或趋势的存在情况。然后，进餐前胰岛素血症的变化作为评估食物摄入期间吸收前胰岛素反应（PIR）的基础。拟合餐前胰岛素振荡的正弦波作为评估PIR的基础似乎并不令人满意。然后根据与置信区间（餐前值的平均值±2标准差）的偏差来定义显著的PIR。当提供的食物更可口时，显著的PIR更频繁出现。出现了个体反应差异。讨论了在自发波动背景下PIR的生理意义。
