Ou Juanfeng, Liu Kun, Jiang Jiamiao, Wilson Daniela A, Liu Lu, Wang Fei, Wang Shuanghu, Tu Yingfeng, Peng Fei
School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.
School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China.
Small. 2020 Jul;16(27):e1906184. doi: 10.1002/smll.201906184. Epub 2020 Mar 4.
Inspired by the highly versatile natural motors, artificial micro-/nanomotors that can convert surrounding energies into mechanical motion and accomplish multiple tasks are devised. In the past few years, micro-/nanomotors have demonstrated significant potential in biomedicine. However, the practical biomedical applications of these small-scale devices are still at an infant stage. For successful bench-to-bed translation, biocompatibility of micro-/nanomotor systems is the central issue to be considered. Herein, the recent progress in micro-/nanomotors in biocompatibility is reviewed, with a special focus on their biomedical applications. Through close collaboration between researches in the nanoengineering, material chemistry, and biomedical fields, it is expected that a promising real-world application platform based on micro-/nanomotors will emerge in the near future.
受多功能天然马达的启发,人们设计出了能够将周围能量转化为机械运动并完成多种任务的人工微纳马达。在过去几年里,微纳马达在生物医学领域展现出了巨大潜力。然而,这些小型装置在生物医学方面的实际应用仍处于起步阶段。为了实现从实验室到临床的成功转化,微纳马达系统的生物相容性是需要考虑的核心问题。在此,本文综述了微纳马达在生物相容性方面的最新进展,特别关注它们在生物医学领域的应用。通过纳米工程、材料化学和生物医学领域研究人员的紧密合作,预计在不久的将来会出现一个基于微纳马达的有前景的实际应用平台。