Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, Los Angeles, CA, USA.
Institute of Applied Health Sciences, King's College, University of Aberdeen, Aberdeen, UK.
Pharmacoeconomics. 2021 Jun;39(6):627-630. doi: 10.1007/s40273-020-00972-w. Epub 2020 Nov 2.
Because depressive symptoms are a part of health-related quality-of-life (HRQOL) measures, measures of depression will be empirically associated with HRQOL. We discuss examples of published research where authors ignored or did not fully account for overlap between depressive symptom and HRQOL measures. Future researchers need to recognize when their models include conceptually similar variables on the same side or both sides of the equation. This awareness will lead to more accurate conclusions about the prognostic value of depression and other HRQOL measures for health care utilization, mortality, and other outcomes. It will also result in fewer incorrect claims about the effect of depression on HRQOL.
因为抑郁症状是健康相关生活质量（HRQOL）衡量标准的一部分，所以衡量抑郁的标准将与 HRQOL 有实证上的关联。我们讨论了一些发表的研究案例，作者忽略或没有充分考虑抑郁症状和 HRQOL 衡量标准之间的重叠。未来的研究人员需要认识到，当他们的模型在等式的同一侧或两侧包含概念上相似的变量时。这种认识将导致对抑郁和其他 HRQOL 衡量标准对医疗保健利用、死亡率和其他结果的预后价值的更准确结论。这也将减少关于抑郁对 HRQOL 影响的错误说法。
