Li Ziwei, Yang Fan, Wu Di, Liu Yanhong, Gao Yang, Lian Haichen, Zhang Hongxin, Yin Zhibin, Wu Aiguo, Zeng Leyong
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Institute of Life Science and Green Development, Hebei University, Baoding 071002, P.R. China.
Nanoscale. 2020 Nov 12;12(43):22173-22184. doi: 10.1039/d0nr05386d.
Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (1O2) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.
转移是乳腺癌治疗失败的主要原因，而集成光诊疗是实现精准诊疗和抑制转移的一种有前景的策略。在这项工作中，合成了一种由二氢卟吩e6（Ce6）共轭且聚多巴胺（PDA）包覆的金纳米星（AuNSs）组成的多功能光诊疗纳米探针，用于同时进行光声（PA）成像、光热疗法（PTT）和光动力疗法（PDT）。在近红外激光照射下，与单一的AuNSs相比，AuNSs@PDA表现出增强的光热转换和放大的PA成像性能。通过Ce6的共价共轭，AuNSs@PDA-Ce6纳米探针表现出强大的稳定性和出色的单线态氧（1O2）生成能力。在PTT/PDT联合作用下，AuNSs@PDA-Ce6纳米探针显著抑制了4T1肿瘤的生长并抑制了其肺转移。所有结果表明，AuNSs@PDA-Ce6光诊疗纳米探针在乳腺癌的精准诊疗和转移抑制方面具有巨大潜力。
