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慢性疾病特殊需求计划与终末期肾病患者住院和死亡的关联。

Association of Chronic Condition Special Needs Plan With Hospitalization and Mortality Among Patients With End-Stage Kidney Disease.

机构信息

DaVita, Inc, Denver, Colorado.

DaVita Clinical Research, Minneapolis, Minnesota.

出版信息

JAMA Netw Open. 2020 Nov 2;3(11):e2023663. doi: 10.1001/jamanetworkopen.2020.23663.

DOI:10.1001/jamanetworkopen.2020.23663
PMID:33136135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7607441/
Abstract

IMPORTANCE

While several studies have demonstrated the benefit of enrollment in chronic condition special needs plans (C-SNPs) for other chronic diseases (eg, diabetes), there is no evaluation of the association of C-SNPs with outcomes among patients with end-stage kidney disease (ESKD).

OBJECTIVE

To examine whether and to what degree C-SNP enrollment was associated with improved clinical outcomes and quality of life in patients with ESKD.

DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study included 2718 patients who were newly enrolled in an ESKD C-SNP between January 1, 2013, and September 30, 2017, and receiving dialysis from DaVita Kidney Care. Patients were followed up until death, loss to follow-up, or end of study (ie, December 31, 2018). Enrollees in C-SNP were matched via multiple clinical and demographic characteristics with 2 different control populations, as follows: (1) those in the same facilities (n = 2545) or (2) those in similar counties (n = 1986). Patients enrolled in CareMore C-SNPs (n = 206) were excluded from the study. Data analysis was conducted June to December 2019.

EXPOSURES

Standard ESKD care with dialysis plus access to an integrated care team who worked with the patient and the dialysis team, comprehensive health assessments done by the integrated care team, and access to select benefits (such as vision and dental care) as a C-SNP enrollee.

MAIN OUTCOMES AND MEASURES

Hospitalizations, mortality, laboratory values indicative of metabolic control, and Kidney Disease Quality of Life 36-item (KDQOL-36) survey scores.

RESULTS

The 2545 C-SNP enrollees in the facility-matched analysis had a mean (SD) age of 57.2 (12.9) years, and included 968 (38.0%) women, 1328 (52.2%) Hispanic individuals, and 553 (21.7%) African American individuals. The 1986 C-SNP enrollees in the county-matched analysis had a mean (SD) age of 57.8 (12.2) years, with 705 (35.5%) women, 1085 (54.6%) Hispanic individuals, and 472 (23.8%) African American individuals. Compared with patients not enrolled in C-SNP, enrollees had lower hospitalization rates, with incidence rate ratios of 0.90 (95% CI, 0.84-0.97; P = .006) in the facility-matched analysis and 0.76 (95% CI, 0.70-0.83; P < .001) in the county-matched analysis. Compared with patients not enrolled in C-SNP, enrollees had decreased mortality risk in the same facilities (hazard ratio, 0.77; 95% CI, 0.68-0.88; P < .001) and in the same counties (hazard ratio, 0.77; 95% CI, 0.66-0.88; P < .001). No significant differences were observed between C-SNP enrollees and matched patients in metabolic laboratory values or KDQOL-36 survey scores.

CONCLUSIONS AND RELEVANCE

This cohort study found a positive association of C-SNP enrollment with lower rates of hospitalization and mortality. The findings suggest that the additional services and benefits C-SNPs provide may improve outcomes compared with standard of care for patients with ESKD.

摘要

重要性

虽然有几项研究已经证明了参与慢性疾病特殊需求计划(C-SNPs)对其他慢性疾病(如糖尿病)的益处,但对于 C-SNPs 与终末期肾病(ESKD)患者的结局之间的关联,还没有评估。

目的

评估 C-SNP 参与是否以及在何种程度上与接受透析的 ESKD 患者的临床结局和生活质量改善相关。

设计、地点和参与者:这项多中心队列研究包括 2718 名于 2013 年 1 月 1 日至 2017 年 9 月 30 日期间新加入 ESKD C-SNP 并接受 DaVita Kidney Care 透析的患者。患者随访至死亡、失访或研究结束(即 2018 年 12 月 31 日)。通过多种临床和人口统计学特征,将 C-SNP 参与者与 2 个不同的对照组进行匹配:(1)同一设施的参与者(n=2545)或(2)类似县的参与者(n=1986)。CareMore C-SNP 的参与者(n=206)被排除在研究之外。数据分析于 2019 年 6 月至 12 月进行。

暴露

接受标准的 ESKD 护理和透析,以及获得一个综合护理团队的服务,该团队与患者和透析团队合作,进行综合健康评估,并作为 C-SNP 参与者获得选择的福利(如视力和牙齿保健)。

主要结果和测量

住院、死亡率、代谢控制的实验室值和 Kidney Disease Quality of Life 36-item(KDQOL-36)调查评分。

结果

在设施匹配分析中,2545 名 C-SNP 参与者的平均(SD)年龄为 57.2(12.9)岁,包括 968 名(38.0%)女性、1328 名(52.2%)西班牙裔个体和 553 名(21.7%)非裔美国人。在县匹配分析中,1986 名 C-SNP 参与者的平均(SD)年龄为 57.8(12.2)岁,其中 705 名(35.5%)为女性、1085 名(54.6%)为西班牙裔个体和 472 名(23.8%)为非裔美国人。与未参加 C-SNP 的患者相比,参与者的住院率较低,设施匹配分析中的发病率比为 0.90(95%CI,0.84-0.97;P=0.006),县匹配分析中的发病率比为 0.76(95%CI,0.70-0.83;P<0.001)。与未参加 C-SNP 的患者相比,同一设施(风险比,0.77;95%CI,0.68-0.88;P<0.001)和同一县(风险比,0.77;95%CI,0.66-0.88;P<0.001)的参与者死亡率风险降低。在代谢实验室值或 KDQOL-36 调查评分方面,C-SNP 参与者与匹配患者之间没有显著差异。

结论和相关性

这项队列研究发现,C-SNP 参与与较低的住院率和死亡率相关。这些发现表明,与 ESKD 患者的标准护理相比,C-SNPs 提供的额外服务和福利可能会改善结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/1f3cf85ff0b3/jamanetwopen-e2023663-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/e795da70fb33/jamanetwopen-e2023663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/516d19efc4e6/jamanetwopen-e2023663-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/1f3cf85ff0b3/jamanetwopen-e2023663-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/e795da70fb33/jamanetwopen-e2023663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/516d19efc4e6/jamanetwopen-e2023663-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/7607441/1f3cf85ff0b3/jamanetwopen-e2023663-g003.jpg

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