Cross J H, Hsu M Y
U.S. Naval Medical Research Unit No. 2, Manila, Philippines.
Southeast Asian J Trop Med Public Health. 1987 Jun;18(2):183-5.
Twelve Mongolian gerbils, Meriones unguiculatus, were infected with 100 third-stage larvae of Wuchereria bancrofti. One month later these animals, along with 4 control animals, were given 100 third-stage larvae of Brugia malayi. Eleven of the 12 experimental animals and the 4 controls survived, and 8 of the experimental animals and all of the controls demonstrated microfilaremia after 3 months. The animals were killed at 6-months post-infection and examined for parasites. One W. bancrofti larva was found in one of the experimental animals, and 15% of the B. malayi given were recovered as adults from the testes, viscera, and carcass. Thirty-eight percent of the worms given to the controls were recovered from the testes, viscera, and pelt. The worms from the experimental animals also appeared to be smaller. This study suggests that gerbils are able to develop partial resistance to Brugia malayi following a previous infection with Wuchereria bancrofti.
将12只长爪沙鼠（Meriones unguiculatus）感染100条班氏吴策线虫第三期幼虫。1个月后，将这些动物与4只对照动物一起感染100条马来布鲁线虫第三期幼虫。12只实验动物中的11只以及4只对照动物存活下来，3个月后，8只实验动物和所有对照动物均出现微丝蚴血症。在感染后6个月处死动物并检查寄生虫。在1只实验动物中发现1条班氏吴策线虫幼虫，从睾丸、内脏和尸体中回收了15%接种的马来布鲁线虫成虫。从对照动物的睾丸、内脏和皮毛中回收了38%接种的蠕虫。实验动物体内的蠕虫似乎也较小。这项研究表明，长爪沙鼠在先前感染班氏吴策线虫后能够对马来布鲁线虫产生部分抗性。
