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miRNAs 和 lncRNAs 在 Epstein-Barr 病毒相关上皮细胞肿瘤中的作用。

The roles of miRNAs and lncRNAs in Epstein-Barr virus associated epithelial cell tumors.

机构信息

Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Shandong, 266021, China.

出版信息

Virus Res. 2021 Jan 2;291:198217. doi: 10.1016/j.virusres.2020.198217. Epub 2020 Nov 1.

Abstract

Epstein-Barr virus (EBV) infection is highly prevalent in the population and is known to be associated with a variety of human tumors, such as nasopharyngeal carcinoma, gastric cancer, and lymphoma; however, the mechanisms of EBV carcinogenesis remain unclear. Recent studies have revealed that many non-coding RNAs participate in the regulation of proliferation, migration, invasion, and other processes in EBV-associated tumor, and the interaction between ncRNAs and the potential target genes has gradually become a research hotspot. Therefore, here, we discuss the expression and roles of ncRNAs in EBV-associated epithelial tumors.

摘要

EB 病毒(EBV)感染在人群中非常普遍,已知与多种人类肿瘤有关,如鼻咽癌、胃癌和淋巴瘤;然而,EBV 致癌的机制仍不清楚。最近的研究表明,许多非编码 RNA 参与 EBV 相关肿瘤中增殖、迁移、侵袭等过程的调节,ncRNA 与潜在靶基因的相互作用逐渐成为研究热点。因此,在这里,我们讨论了 ncRNA 在 EBV 相关上皮肿瘤中的表达和作用。

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