Svensson Fredric G, Seisenbaeva Gulaim A, Kotov Nicholas A, Kessler Vadim G
Department of Molecular Sciences, Swedish University of Agricultural Sciences (SLU), Box 7015, 75007 Uppsala, Sweden.
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Materials (Basel). 2020 Oct 29;13(21):4856. doi: 10.3390/ma13214856.
Titania (anatase) nanoparticles were anisotropically functionalized in water-toluene Pickering emulsions to self-assemble into nanoshells with diameters from 500 nm to 3 μm as candidates for encapsulation of drugs and other compounds. The water-phase contained a hydrophilic ligand, glucose-6-phosphate, while the toluene-phase contained a hydrophobic ligand, n-dodecylphosphonic acid. The addition of a dilute sodium alginate suspension that provided electrostatic charge was essential for the self-limited assembly of the nanoshells. The self-assembled spheres were characterized by scanning electron microscopy, elemental mapping, and atomic force microscopy. Drug release studies using tetracycline suggest a rapid release dominated by surface desorption.
在水 - 甲苯皮克林乳液中对二氧化钛（锐钛矿型）纳米颗粒进行各向异性功能化处理，使其自组装成直径为500纳米至3微米的纳米壳，作为药物和其他化合物封装的候选材料。水相中含有亲水性配体6 - 磷酸葡萄糖，而甲苯相中含有疏水性配体正十二烷基膦酸。添加提供静电荷的稀海藻酸钠悬浮液对于纳米壳的自限性组装至关重要。通过扫描电子显微镜、元素映射和原子力显微镜对自组装球体进行了表征。使用四环素的药物释放研究表明，表面解吸主导了快速释放。
