Evdokimova Olga L, Svensson Fredric G, Agafonov Alexander V, Håkansson Sebastian, Seisenbaeva Gulaim A, Kessler Vadim G
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya St.1, 153045 Ivanovo, Russia.
Department of Molecular Sciences, BioCenter, Swedish University of Agricultural Science, 750 07 Uppsala, Sweden.
Nanomaterials (Basel). 2018 Apr 8;8(4):228. doi: 10.3390/nano8040228.
Spherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production. Cellulose nanocrystals were extracted via a simple and quick two-step process based on first the complexation with Cu(II) solution in aqueous ammonia followed by acid hydrolysis with diluted H₂SO₄. Triclosan was selected as a model drug for complexation with titania and further introduction into the nanocellulose based composite. Obtained materials were characterized by a broad variety of microscopic, spectroscopic, and thermal analysis methods. The drug release studies showed long-term release profiles of triclosan from the titania based nanocomposite that agreed with Higuchi model. The bacterial susceptibility tests demonstrated that released triclosan retained its antibacterial activity against and . It was found that a small amount of titania significantly improved the antibacterial activity of obtained nanocomposites, even without immobilization of model drug. Thus, the developed hybrid patches are highly promising candidates for potential application as antibacterial agents.
成功制备了接枝有二氧化钛纳米粒子的基于球形纤维素纳米晶体的杂化材料用于局部药物递送。传统的分析滤纸用作纤维素纳米晶体（CNC）生产的前体材料。纤维素纳米晶体通过简单快速的两步法提取，首先是在氨水溶液中与Cu（II）溶液络合，然后用稀H₂SO₄进行酸水解。选择三氯生作为与二氧化钛络合并进一步引入基于纳米纤维素的复合材料的模型药物。通过多种显微镜、光谱和热分析方法对所得材料进行表征。药物释放研究表明，三氯生从基于二氧化钛的纳米复合材料中的长期释放曲线符合Higuchi模型。细菌敏感性测试表明，释放的三氯生对……和……保留其抗菌活性。发现少量的二氧化钛显著提高了所得纳米复合材料的抗菌活性，即使没有固定模型药物。因此，所开发的杂化贴片作为抗菌剂具有潜在应用的高度前景。
