Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch, New Zealand.
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Antioxid Redox Signal. 2021 Jun 10;34(17):1368-1377. doi: 10.1089/ars.2020.8211. Epub 2020 Dec 2.
Inflammation is a normal response to injury, but uncontrolled inflammation can lead to several diseases. In recent years, research has shown endogenously synthesized hydrogen sulfide (HS) to be a novel mediator of inflammation. This review summarizes the current understanding and recent advances of HS role with respect to inflammation in different diseases. Promising early results from clinical studies suggest an important role of HS in human inflammatory disease. Defining the precise mechanism by which HS contributes to inflammation is a complex challenge, and there is active ongoing research that is focused on addressing this question. Most of this work has been conducted on animal models of human disease and isolated/cultured cells, and its translation to the clinic is another challenge in the area of HS research. Defining the mechanism by which HS acts as an inflammatory mediator will help us better understand different inflammatory diseases and help develop novel therapeutic approaches for these diseases.
炎症是对损伤的正常反应，但失控的炎症会导致几种疾病。近年来，研究表明内源性合成的硫化氢（HS）是炎症的一种新型介质。本综述总结了目前对 HS 在不同疾病中炎症作用的理解和最新进展。来自临床研究的有希望的初步结果表明 HS 在人类炎症性疾病中具有重要作用。确定 HS 参与炎症的确切机制是一个复杂的挑战，目前有大量的研究集中在解决这个问题上。这项工作大多是在人类疾病的动物模型和分离/培养的细胞上进行的，将其转化到临床应用是 HS 研究领域的另一个挑战。确定 HS 作为炎症介质的作用机制将有助于我们更好地了解不同的炎症性疾病，并有助于为这些疾病开发新的治疗方法。
