Department of Pharmacy, Jagannath University, Sadarghat, Dhaka-1100, Bangladesh.
Department of Pharmacy, Southeast University, Banani, Dhaka-1213, South Korea.
Curr Pharm Des. 2021;27(3):345-356. doi: 10.2174/1381612826666201102102810.
Aging is a normal human cycle and the most important risk factor for neurodegenerative diseases. Alternations in cells due to aging contribute to loss of the nutrient-sensing, cell function, increased oxidative stress, loss of the homeostasis cell, genomic instability, the build-up of malfunctioning proteins, weakened cellular defenses, and a telomere split. Disturbance of these essential cellular processes in neuronal cells can lead to life threats including Alzheimer's disease (AD), Huntington's disease (HD), Lewy's disease, etc. The most common cause of death in the elderly population is AD. Specific therapeutic molecules were created to alleviate AD's social, economic, and health burden. In clinical practice, almost every chemical compound was found to relieve symptoms only in palliative treatment. The reason behind these perfect medicines is that the current medicines are not effective in targeting the cause of this disease. In this paper, we explored the potential role of flavonoid and polyphenolic compounds, which could be the most effective preventative anti-Alzheimer's strategy.
衰老是一个正常的人类周期，也是神经退行性疾病的最重要的风险因素。由于衰老导致的细胞改变会导致营养感应丧失、细胞功能下降、氧化应激增加、细胞内稳态丧失、基因组不稳定、功能失调蛋白质堆积、细胞防御减弱以及端粒分裂。神经元细胞中这些重要的细胞过程的紊乱会导致生命威胁，包括阿尔茨海默病（AD）、亨廷顿病（HD）、路易体病等。老年人中最常见的死因是 AD。特定的治疗分子被创造出来以减轻 AD 的社会、经济和健康负担。在临床实践中，几乎所有的化学化合物都被发现只能在姑息治疗中缓解症状。这些完美药物背后的原因是，目前的药物在针对这种疾病的病因方面效果不佳。在本文中，我们探讨了类黄酮和多酚化合物的潜在作用，它们可能是最有效的预防阿尔茨海默病的策略。
