推进饮食失调研究的替代框架。
Alternative Frameworks for Advancing the Study of Eating Disorders.
作者信息
Stern Sarah A, Bulik Cynthia M
机构信息
Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA; Department of Molecular Genetics, Rockefeller University, New York, NY, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Trends Neurosci. 2020 Dec;43(12):951-959. doi: 10.1016/j.tins.2020.10.001. Epub 2020 Oct 31.
Eating disorders are life-interrupting psychiatric conditions with high morbidity and mortality, yet the basic mechanisms underlying these conditions are understudied compared with other psychiatric disorders. In this opinion, we suggest that recent knowledge gleaned from genomic and neuroimaging investigations of eating disorders in humans presents a rich opportunity to sharpen animal models of eating disorders and to identify neural mechanisms that contribute to the risk and maintenance of these conditions. Our article reflects the state of the science, with a primary focus on anorexia nervosa (AN) and binge-eating behavior, and encourages further study of all conditions categorized under feeding and eating disorders.
饮食失调是严重影响生活的精神疾病，发病率和死亡率都很高，但与其他精神疾病相比，这些疾病的基本机制尚未得到充分研究。在本文中，我们认为，最近从人类饮食失调的基因组和神经影像学研究中获得的知识，为完善饮食失调的动物模型以及识别导致这些疾病风险和持续存在的神经机制提供了丰富的机会。我们的文章反映了科学现状，主要关注神经性厌食症（AN）和暴饮暴食行为，并鼓励对归类于进食障碍的所有疾病进行进一步研究。
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