胰腺疾病与微生物群：文献综述及未来展望
Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives.
作者信息
Gesualdo Marcantonio, Rizzi Felice, Bonetto Silvia, Rizza Stefano, Cravero Federico, Saracco Giorgio Maria, De Angelis Claudio Giovanni
机构信息
Gastroenterology and Digestive Endoscopy Unit, AOU Città della Salute e della Scienza, University of Turin, 10126 Turin, Italy.
出版信息
J Clin Med. 2020 Nov 1;9(11):3535. doi: 10.3390/jcm9113535.
Gut microbiota represent an interesting worldwide research area. Several studies confirm that microbiota has a key role in human diseases, both intestinal (such as inflammatory bowel disease, celiac disease, intestinal infectious diseases, irritable bowel syndrome) and extra intestinal disorders (such as autism, multiple sclerosis, rheumatologic diseases). Nowadays, it is possible to manipulate microbiota by administering prebiotics, probiotics or synbiotics, through fecal microbiota transplantation in selected cases. In this scenario, pancreatic disorders might be influenced by gut microbiota and this relationship could be an innovative and inspiring field of research. However, data are still scarce and controversial. Microbiota manipulation could represent an important therapeutic strategy in the pancreatic diseases, in addition to standard therapies. In this review, we analyze current knowledge about correlation between gut microbiota and pancreatic diseases, by discussing on the one hand existing data and on the other hand future possible perspectives.
肠道微生物群是一个有趣的全球研究领域。多项研究证实，微生物群在人类疾病中起着关键作用，包括肠道疾病（如炎症性肠病、乳糜泻、肠道传染病、肠易激综合征）和肠道外疾病（如自闭症、多发性硬化症、风湿性疾病）。如今，通过施用益生元、益生菌或合生元，以及在特定情况下进行粪便微生物群移植，有可能对微生物群进行调控。在这种情况下，胰腺疾病可能会受到肠道微生物群的影响，这种关系可能是一个创新且鼓舞人心的研究领域。然而，相关数据仍然稀少且存在争议。除了标准疗法外，微生物群调控可能是胰腺疾病的一种重要治疗策略。在这篇综述中，我们一方面通过讨论现有数据，另一方面通过探讨未来可能的前景，来分析目前关于肠道微生物群与胰腺疾病之间相关性的知识。
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