Leivonen Susanna, Voutilainen Arja, Hinkka-Yli-Salomäki Susanna, Timonen-Soivio Laura, Chudal Roshan, Gissler Mika, Huttunen Jukka, Sourander Andre
Department of Child Psychiatry, University of Turku, Turku, Finland; Children's Hospital, Child Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Acta Paediatr. 2014 Sep;103(9):984-90. doi: 10.1111/apa.12708. Epub 2014 Aug 1.
The aim of this study was to describe the characteristics and incidence rates of diagnosed tic disorders in the Finnish Hospital Discharge Register, including changing incidence rates between 1991 and 2010. We also aimed to validate the diagnoses of Tourette's syndrome recorded in the register.
Children born between January 1, 1991 and December 31, 2010, who were diagnosed with tic disorders, were identified from the Finnish Hospital Discharge Register (n = 3003). We studied the validity of the Tourette's syndrome diagnoses by reviewing the medical charts of 88 children born since 1997 and carrying out telephone interviews with 55 of their guardians.
The incidence rates of all diagnosed tic disorders increased during the study period. A comorbid diagnosis of hyperkinetic disorder diagnosis was recorded in 28.2% of the children with Tourette's syndrome, and the validity of the register-based Tourette's syndrome diagnosis was approximately 95%.
This is the first nationwide study to demonstrate the increasing incidence of all register-based tic disorder diagnoses. The validity of the Tourette's syndrome diagnoses in the Finnish Hospital Discharge Register was good, and the data provided are suitable for use in further register-based studies of tic disorders.
本研究旨在描述芬兰医院出院登记册中确诊抽动障碍的特征和发病率，包括1991年至2010年间发病率的变化情况。我们还旨在验证登记册中记录的妥瑞氏综合征的诊断。
从芬兰医院出院登记册中识别出1991年1月1日至2010年12月31日出生且被诊断为抽动障碍的儿童（n = 3003）。我们通过查阅自1997年以来出生的88名儿童的病历并对其中55名儿童的监护人进行电话访谈，研究了妥瑞氏综合征诊断的有效性。
在研究期间，所有确诊抽动障碍的发病率均有所上升。28.2%的妥瑞氏综合征患儿同时被诊断为多动障碍，基于登记册的妥瑞氏综合征诊断的有效性约为95%。
这是第一项全国性研究，证明了所有基于登记册的抽动障碍诊断的发病率都在上升。芬兰医院出院登记册中妥瑞氏综合征诊断的有效性良好，所提供的数据适用于进一步基于登记册的抽动障碍研究。
