Suppr超能文献

层状双氢氧化物作为癌症诊疗一体化纳米平台的最新进展。

Recent progress in layered double hydroxides as a cancer theranostic nanoplatform.

机构信息

Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea.

College of Science and Technology, Dankook University, Cheonan, Republic of Korea.

出版信息

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Mar;13(2):e1679. doi: 10.1002/wnan.1679. Epub 2020 Nov 2.

Abstract

Layered double hydroxide (LDH) has been a big challenge in exploring new hybrid materials by intercalating inorganic, organic, or bio molecules into their lamellar lattice, those which often showed dual functions from each other or new mutative properties. Recently, nano-bio convergence technology becomes one of the most extensively studied research fields in the view point of developing advanced drugs and diagnostic agents to fight against disease and eventually to improve the lives of human beings. Therefore, LDH as one of the nanomaterials have been intensively investigated not only as biocompatible drug delivery vehicle for cancer chemotherapy but also as diagnostic and imaging agents. In the present review, we have attempted to summarize theranostic functions of drug-LDH hybrid nanoparticles including their synthetic methods, physico-chemical and biological properties, and their unique mechanism overcoming drug resistance, and targeting properties based on in vitro and finally in vivo results. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > in vivo Nanodiagnostics and Imaging.

摘要

层状双氢氧化物(LDH)通过将无机、有机或生物分子插入其层状晶格中,一直是探索新型杂化材料的一大挑战,这些材料通常表现出相互的双重功能或新的突变性质。最近,纳米生物融合技术成为最广泛研究的领域之一,从开发先进的药物和诊断剂的角度来看,以对抗疾病并最终改善人类的生活。因此,LDH 作为纳米材料之一,不仅被广泛研究为用于癌症化疗的生物相容性药物输送载体,还被研究为诊断和成像剂。在本综述中,我们试图总结载药 LDH 杂化纳米粒子的治疗诊断功能,包括它们的合成方法、物理化学和生物学特性,以及它们基于体外和最终体内结果克服药物耐药性和靶向特性的独特机制。本文属于以下分类:诊断工具 > 诊断纳米器件 诊断工具 > 体内纳米诊断和成像。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验