Department of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX, USA.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
Immunol Cell Biol. 2021 Apr;99(4):351-360. doi: 10.1111/imcb.12422. Epub 2020 Nov 24.
Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.
在过去的十年中，自噬已成为免疫系统的一个关键调节机制，通过严格控制 T 细胞生物学的各个方面并决定不同 T 细胞亚群的命运来实现这一点。自噬通过调节细胞器和凋亡蛋白的降解来维持 T 细胞的发育和存活。自噬过程也会影响记忆 T 细胞的形成。T 细胞中自噬的改变可能导致各种病理状况，如炎症、自身免疫性疾病和癌症。在这篇综述中，我们讨论了自噬如何影响 T 细胞的分化、存活和记忆，以及它在各种疾病的免疫治疗中的意义。
