Department of Thoracic Surgery, Beijing Aerospace General Hospital, Wanyuan North Road, Beijing 100076, China.
Department of Pediatric intensive care unit, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, North Lishi Road, Beijing 100037, China.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111508. doi: 10.1016/j.ecoenv.2020.111508. Epub 2020 Nov 1.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with several risk factors. Recent studies have suggested that the exposure to air pollutants may increase the prevalence of AF, we evaluated those studies systematically to better elucidate the correlation between exposure to air pollution and AF.
We conducted a systematic review of publications using PubMed, Embase, the Cochrane library and Web of Science to explore the association between air pollutants and AF within the general population. The chosen studies were published until 7 July 2020. According to different study designs, we divided the outcomes into "short-term-exposure group" and "long-term-exposure group" for each pollutant. We used I statistics and Q-test to examine statistical heterogeneity, and sensitivity analysis to exclude the heterogeneous study. Fixed or random-effect model was used to combine the effects. Final result was presented as the OR and 95% CI of AF prevalence for every 10 μg/m increase in the concentration of PM and PM;10 ppb increase in the concentration of SO ,NO ,O; and 1 ppm increase in the CO concentration.
Our analysis contain 18 studies. Underlying short-term exposure effect, for each increment of 10 μg/m in the PM concentration, the combined OR of AF prevalence was 1.01(1.00-1.02), for PM was 1.03(1.01-1.05). For a 10 ppb increment in the concentration of SO, NO, and O was 1.05(1.01-1.09), 1.03(1.01-1.04), and 1.01(0.97-1.06), respectively, for a 1 ppm increase of CO concentration was 1.02(0.99-1.06). Underlying long-term-exposure effect for each increment of 10 μg/m in the PM concentration; the combined OR of AF prevalence was 1.07(1.04-1.10) and that for PM was 1.03(1.03-1.04) For a 10 ppb increment in the NO concentration was 1.02(1.00-1.04).
Our meta-analysis indicated that all air pollutants exposure had an adverse effect on AF prevalence in general population.
心房颤动（AF）是最常见的持续性心律失常，有多种危险因素。最近的研究表明，暴露于空气污染物可能会增加 AF 的患病率，我们系统地评估了这些研究，以更好地阐明暴露于空气污染与 AF 之间的相关性。
我们使用 PubMed、Embase、Cochrane 图书馆和 Web of Science 进行了系统的文献检索，以探讨一般人群中空气污染物与 AF 之间的关联。选择的研究截至 2020 年 7 月 7 日发表。根据不同的研究设计，我们将结果分为“短期暴露组”和“长期暴露组”，用于每种污染物。我们使用 I 统计量和 Q 检验来检验统计异质性，并进行敏感性分析以排除异质研究。使用固定或随机效应模型来合并效应。最终结果以每增加 10μg/m3 的 PM 和 PM 浓度、每增加 10ppb 的 SO、NO、O 浓度和每增加 1ppm 的 CO 浓度时 AF 患病率的 OR 和 95%CI 表示。
我们的分析包含 18 项研究。在短期暴露效应下，PM 浓度每增加 10μg/m3，AF 患病率的合并 OR 为 1.01（1.00-1.02），PM 为 1.03（1.01-1.05）。SO、NO 和 O 浓度每增加 10ppb，AF 患病率的合并 OR 分别为 1.05（1.01-1.09）、1.03（1.01-1.04）和 1.01（0.97-1.06），CO 浓度每增加 1ppm，合并 OR 为 1.02（0.99-1.06）。在长期暴露效应下，PM 浓度每增加 10μg/m3，AF 患病率的合并 OR 为 1.07（1.04-1.10），PM 为 1.03（1.03-1.04）。NO 浓度每增加 10ppb，AF 患病率的合并 OR 为 1.02（1.00-1.04）。
我们的荟萃分析表明，所有空气污染物暴露均对一般人群的 AF 患病率产生不利影响。
