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空气污染与心血管疾病:作用机制、证据及缓解策略。

Air pollution and cardiovascular diseases: mechanisms, evidence, and mitigation strategies.

作者信息

Krismanuel Hari

机构信息

Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia.

出版信息

J Med Life. 2025 May;18(5):411-427. doi: 10.25122/jml-2025-0018.

Abstract

One of the most urgent environmental health issues is air pollution, which has a major effect on cardiovascular health. Among other pollutants, fine particulate matter (PM2.5) has been connected to a number of cardiovascular illnesses (CVDs), including myocardial infarction, stroke, and hypertension. The purpose of this review was to summarize current research on the processes by which air pollution raises the risk of CVD and to investigate mitigation and preventative measures. A review of peer-reviewed articles published between 2015 and 2025 was conducted using databases such as PubMed, Web of Science, and Google Scholar. The review focused on studies examining the relationship between PM2.5 and cardiovascular diseases, incorporating epidemiological, experimental, and clinical perspectives. PM2.5 and other pollutants exacerbate CVD risk through mechanisms such as autonomic instability, endothelial dysfunction, oxidative stress, and inflammation. Risks are disproportionately high for vulnerable groups, such as the elderly and those with underlying cardiovascular diseases. Targeted public health policies, stricter air quality regulations, and increased public awareness are essential to mitigate the cardiovascular risks posed by air pollution. Immediate action is imperative to safeguard global health.

摘要

最紧迫的环境卫生问题之一是空气污染,它对心血管健康有重大影响。在其他污染物中,细颗粒物(PM2.5)与多种心血管疾病(CVD)有关,包括心肌梗死、中风和高血压。本综述的目的是总结当前关于空气污染增加心血管疾病风险的过程的研究,并探讨缓解和预防措施。使用PubMed、科学网和谷歌学术等数据库对2015年至2025年间发表的同行评议文章进行了综述。该综述重点关注研究PM2.5与心血管疾病之间关系的研究,纳入了流行病学、实验和临床视角。PM2.5和其他污染物通过自主神经不稳定、内皮功能障碍、氧化应激和炎症等机制加剧心血管疾病风险。弱势群体,如老年人和患有潜在心血管疾病的人,面临的风险尤其高。有针对性的公共卫生政策、更严格的空气质量法规以及提高公众意识对于减轻空气污染带来的心血管风险至关重要。立即采取行动对于保障全球健康势在必行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8087/12207690/e4764cb225f2/JMedLife-18-411-g001.jpg

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