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植物介导的使用水果提取物合成银纳米粒子及其细胞毒性和抗菌潜力评价。

Phyto-Mediated Synthesis of Silver Nanoparticles Using Fruit Extract and Evaluation of Its Cytotoxic and Antimicrobial Potential.

机构信息

Department of Chemistry, Bangalore Institute of Technology, K.R. Road, V.V. Puram, Karnataka, Bangalore 560 004, India.

Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Karnataka 570 026, India.

出版信息

Molecules. 2020 Oct 30;25(21):5042. doi: 10.3390/molecules25215042.

DOI:10.3390/molecules25215042
PMID:33143044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7662631/
Abstract

The increasing interest in developing potent non-toxic drugs in medicine is widening the opportunities for studying the usage of nanostructures in the treatment of various diseases. The present work reports a method for a facile and an eco-friendly synthesis of silver nanoparticles (AgNPs) using fruit extract (TCE). The obtained AgNPs was characterized by using different spectroscopic and microscopic techniques. The analysis of the results revealed that the as-obtained AgNPs have spherical morphology with an average diameter of 22 nm. Furthermore, the preliminary bioactivity evaluations revealed that the bio-conjugation of AgNPs, using TCE, significantly enhanced the antibacterial and anti-breast cancer potentials of the latter. The antibacterial activity of the as-prepared AgNPs showed that was more sensitive towards the AgNPs, followed by ; while, and showed comparatively minimal sensitivity toward the AgNPs. The IC values of TCE, AgNPs and TCE + AgNPs treatment of MCF-7 were found to be 17.53, 14.25 and 6.484 µg/mL, respectively. Therefore, it can be ascertained that the bio-conjugation may provide a headway with regard to the therapeutic employment of , upon mechanistically understanding the basis of observed antibacterial and anticancer activities.

摘要

在医学领域开发高效无毒药物的兴趣日益浓厚，这为研究纳米结构在治疗各种疾病中的应用提供了更多机会。本工作报道了一种使用水果提取物（TCE）简便、环保的合成银纳米粒子（AgNPs）的方法。通过使用不同的光谱和显微镜技术对所得 AgNPs 进行了表征。结果分析表明，所获得的 AgNPs 具有球形形态，平均直径为 22nm。此外，初步的生物活性评价表明，使用 TCE 进行 AgNPs 的生物缀合，显著提高了后者的抗菌和抗乳腺癌潜力。所制备的 AgNPs 的抗菌活性表明，对 AgNPs 更为敏感，其次是 ；而 和 对 AgNPs 的敏感性相对较低。TCE、AgNPs 和 TCE+AgNPs 处理 MCF-7 的 IC 值分别为 17.53、14.25 和 6.484µg/mL。因此，可以确定，在从机制上理解观察到的抗菌和抗癌活性的基础上，生物缀合可能为 的治疗应用提供了一个突破口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/0a11ebca7530/molecules-25-05042-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/3dd5f23976d5/molecules-25-05042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/9ff3e70e40df/molecules-25-05042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/8f4d983bb241/molecules-25-05042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/0a11ebca7530/molecules-25-05042-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/3dd5f23976d5/molecules-25-05042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/9ff3e70e40df/molecules-25-05042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/8f4d983bb241/molecules-25-05042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f032/7662631/0a11ebca7530/molecules-25-05042-g004.jpg

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