Department of Biotechnology, Dayananda Sagar College of Engineering, (Affiliated to VTU, Belagavi), Shavige Malleshwara Hills, Bengaluru 560078, Karnataka, India.
Ramaiah Medical College and Hospitals, New BEL Road, Bengaluru 560054, Karnataka, India.
Molecules. 2022 Apr 10;27(8):2442. doi: 10.3390/molecules27082442.
Cancer is one of the leading causes of death worldwide, accountable for a total of 10 million deaths in the year 2020, according to GLOBOCAN 2020. The advancements in the field of cancer research indicate the need for direction towards the development of new drug candidates that are instrumental in a tumour-specific action. The pool of natural compounds proves to be a promising avenue for the discovery of groundbreaking cancer therapeutics. (Rudraksha) is known to possess antioxidant properties and after a thorough review of literature, it was speculated to possess significant biomedical potential. Green synthesis of nanoparticles is an environmentally friendly approach intended to eliminate toxic waste and reduce energy consumption. This approach was reported for the synthesis of silver nanoparticles from two different solvent extracts: aqueous and methanolic. These were characterized by biophysical and spectroscopic techniques, namely, UV-Visible Spectroscopy, FTIR, XRD, EDX, DLS, SEM, and GC-MS. The results showed that the nanoconjugates were spherical in geometry. Further, the assessment of antibacterial, antifungal, and antiproliferative activities was conducted which yielded results that were qualitatively positive at the nanoscale. The nanoconjugates were also evaluated for their anticancer properties using a standard MTT Assay. The interactions between the phytochemicals (ligands) and selected cancer receptors were also visualized in silico using the PyRx tool for molecular docking.
癌症是全球主要死因之一，根据 2020 年 GLOBOCAN 的数据，2020 年全球共有 1000 万人因癌症死亡。癌症研究领域的进展表明，需要开发新的候选药物，这些药物对于肿瘤特异性作用至关重要。天然化合物库被证明是发现突破性癌症治疗方法的有前途的途径。（Rudraksha）被认为具有抗氧化特性，在对文献进行全面审查后，人们推测它具有重要的生物医学潜力。纳米粒子的绿色合成是一种环保方法，旨在消除有毒废物和减少能源消耗。已经报道了从两种不同溶剂提取物：水和甲醇中合成银纳米粒子的这种方法。这些提取物通过生物物理和光谱技术进行了表征，即紫外-可见光谱、傅里叶变换红外光谱、X 射线衍射、能谱、动态光散射、扫描电子显微镜和气相色谱-质谱。结果表明，纳米复合物具有球形几何形状。此外，还进行了抗菌、抗真菌和抗增殖活性评估，结果在纳米尺度上定性为阳性。还使用标准 MTT 测定法评估了纳米复合物的抗癌特性。还使用 PyRx 工具进行分子对接，在计算机上可视化了植物化学物质（配体）与选定的癌症受体之间的相互作用。
