Medical School, Institute of Migration Health, University of Pécs, Pécs, Hungary
Department of Public Health Medicine, University of Pécs, Pécs, Hungary.
In Vivo. 2020 Nov-Dec;34(6):3467-3472. doi: 10.21873/invivo.12186.
BACKGROUND/AIM: With a prevalence of 50-300 per 100,000 people, about 2.3 million people are estimated to live with multiple sclerosis (MS) globally. The role of antibiotics in the development, or prevention of MS is controversial. We aimed to elucidate the association between antibiotic consumption and MS.
Pearson statistical comparisons were performed between the annual average antibiotic consumption patterns expressed in Defined Daily Dose/1,000 inhabitants/Day of the antibiotic consumption for the years of 1997-2018 in 30 European countries, with the respective prevalence of MS estimated for 2016.
A positive correlation (promoting effect) has been observed between narrow spectrum penicillin (r=0.636) and tetracycline (r=0.412) consumption with MS prevalence.
Countries, with high consumption of narrow spectrum penicillin and tetracycline, experience a higher prevalence of MS than other countries.
背景/目的：多发性硬化症（MS）的全球患病率为每 10 万人中有 50-300 人，估计全球有 230 万人患有多发性硬化症。抗生素在 MS 的发展或预防中的作用存在争议。我们旨在阐明抗生素的使用与 MS 之间的关联。
对 1997 年至 2018 年间 30 个欧洲国家的抗生素使用情况进行了年度平均抗生素使用模式（以每千名居民每天使用的限定日剂量表示）的皮尔逊统计比较，并对 2016 年估计的多发性硬化症的相应患病率进行了比较。
窄谱青霉素（r=0.636）和四环素（r=0.412）的使用与 MS 的流行呈正相关（促进作用）。
与其他国家相比，窄谱青霉素和四环素消耗量大的国家多发性硬化症的患病率更高。
