Draelos Zoe Diana
Dr. Draelos is with Dermatology Consulting Services, PLLC in High Point, North Carolina.
J Clin Aesthet Dermatol. 2020 Apr;13(4):36-38. Epub 2020 Apr 1.
Folliculitis is a frequently recurrent skin condition characterized by inflammatory papules and pustules on numerous body areas arising from follicular irritation induced by shaving or trauma but might also arise in the presence of bacterial or fungal organisms. Oral and topical antibiotics remain the mainstay of treatment, but the chronicity of the condition requires a safe maintenance therapy. The objective of this study was to examine the off-label use of 15% azelaic acid foam in the treatment of folliculitis. Subjects received 15% azelaic acid foam for twice daily application to all areas of folliculitis for four weeks. Twenty-six male or female subjects with dermatologist diagnosed folliculitis participated in this research. Assessments consisted of the dermatologist investigator and subjects evaluating several parameters on a five-point scale (0=none, 1=minimal, 2=mild, 3=moderate, 4=severe) at baseline, Week 2, and Week 4. The dermatologist investigator evaluated lesional erythema, lesional inflammatory papule size, extent of inflammatory papules, lesional pus, lesional pustule size, extent of pustules, and overall folliculitis assessment. The subjects assessed itching associated with folliculitis, pain associated with folliculitis, lesional pus, lesional redness, extent of involvement, and overall folliculitis assessment. After four weeks of 15% azelaic acid foam treatment, the investigator noted a 67-percent reduction in lesional erythema, 73-percent reduction in lesional inflammatory papule size, 87-percent reduction in extent of pustules, and 78-percent reduction in overall folliculitis. The subjects reported a reduction of 60-percent in folliculitis itching, 67-percent reduction in pain, 73-percent reduction in lesional pus, 51-percent reduction in lesional redness, and 59-percent reduction in extent of folliculitis involvement. Azelaic acid 15% foam used off-label might be a useful treatment or adjunctive therapy for folliculitis.
毛囊炎是一种经常复发的皮肤疾病，其特征是在身体多个部位出现炎性丘疹和脓疱，这些症状由剃须或外伤引起的毛囊刺激导致，但在存在细菌或真菌的情况下也可能出现。口服和外用抗生素仍然是主要的治疗方法，但该疾病的慢性特性需要一种安全的维持疗法。本研究的目的是检验15%壬二酸泡沫在治疗毛囊炎中的超说明书用药情况。受试者每天两次在所有毛囊炎部位涂抹15%壬二酸泡沫，持续四周。26名经皮肤科医生诊断为毛囊炎的男性或女性受试者参与了本研究。评估包括皮肤科医生研究者和受试者在基线、第2周和第4周时对几个参数进行五分制评分（0 = 无，1 = 轻微，2 = 轻度，3 = 中度，4 = 重度）。皮肤科医生研究者评估皮损红斑、皮损炎性丘疹大小、炎性丘疹范围、皮损脓液、皮损脓疱大小、脓疱范围以及整体毛囊炎评估。受试者评估与毛囊炎相关的瘙痒、与毛囊炎相关的疼痛、皮损脓液、皮损发红、受累范围以及整体毛囊炎评估。在15%壬二酸泡沫治疗四周后，研究者发现皮损红斑减少了67%，皮损炎性丘疹大小减少了73%，脓疱范围减少了87%，整体毛囊炎减少了78%。受试者报告毛囊炎瘙痒减少了60%，疼痛减少了67%，皮损脓液减少了73%，皮损发红减少了51%，毛囊炎受累范围减少了59%。15%壬二酸泡沫的超说明书使用可能是治疗毛囊炎的一种有效方法或辅助疗法。
